ArticleMovement disorders : official journal of the Movement Disorder Society2015
Spotlight on movement disorders: What optogenetics has to offer.
Article in Movement disorders : official journal of the Movement Disorder Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Electrophysiological insights into deep brain stimulation of the network disorder dystonia.Pflugers Archiv : European journal of physiology · 2023Review
- Light-Controlled Modulation and Analysis of Neuronal Functions.International journal of molecular sciences · 2022Article
- New Targets and New Technologies in the Treatment of Parkinson's Disease: A Narrative Review.International journal of environmental research and public health · 2022Review
- Optogenetic Neuronal Stimulation Promotes Functional Recovery After Spinal Cord Injury.Frontiers in neuroscience · 2021Article
- Mediodorsal Thalamus Contributes to the Timing of Instrumental Actions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Optogenetic augmentation of the hypercholinergic endophenotype in DYT1 knock-in mice induced erratic hyperactive movements but not dystonia.EBioMedicine · 2019Article
- Light-induced regulation of ligand-gated channel activity.British journal of pharmacology · 2018Review
- Synaptic plasticity may underlie l-DOPA induced dyskinesia.Current opinion in neurobiology · 2018Review
- Genetic manipulation for inherited neurodegenerative diseases: myth or reality?The British journal of ophthalmology · 2016Review
- Viral vector-based tools advance knowledge of basal ganglia anatomy and physiology.Journal of neurophysiology · 2016Review
- Analyzing 7000 texts on deep brain stimulation: what do they tell us?Frontiers in integrative neuroscience · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Elucidating the neuronal mechanisms underlying movement disorders is a major challenge because of the intricacy of the relevant neural circuits, which are characterized by diverse cell types and complex connectivity. A major limitation of traditional techniques, such as electrical stimulation or lesions, is that individual elements of a neural circuit cannot be selectively manipulated. Moreover, available treatments are largely based on trial and error rather than a detailed understanding of the circuit mechanisms. Gaps in our knowledge of the circuit mechanisms for movement disorders, as well as mechanisms underlying known treatments such as deep brain stimulation, make it difficult to design new and improved treatment options. In this perspective, we discuss how optogenetics, which allows researchers to use light to manipulate neuronal activity, can contribute to the understanding and treatment of movement disorders. We outline the advantages and limitations of optogenetics and discuss examples of studies that have used this tool to clarify the role of the basal ganglia circuitry in movement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.