Evidence map›Paper›PMID 25777781›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2016

The reproducibility of time-of-flight PET and conventional PET for the quantification of myocardial blood flow and coronary flow reserve with (13)N-ammonia.

Masaya Suda, Masahisa Onoguchi, Takeshi Tomiyama, Keiichi Ishihara, Naoto Takahashi, Minoru Sakurai, Keiichi Matsumoto, Shin-Ichiro Kumita

Abstract readComparative StudyEvaluation StudyValidation Study
PubMed Publisher
In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. EANM procedural guidelines for PET/CT quantitative myocardial perfusion imaging.European journal of nuclear medicine and molecular imaging · 2021
    Article
  4. Radiopharmaceutical tracers for cardiac imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018
    Article
  5. Review
  6. Review
  7. How to reconstruct dynamic cardiac PET data?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017
    Article
  8. ASNC imaging guidelines/SNMMI procedure standard for positron emission tomography (PET) nuclear cardiology procedures.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016
    Article
  9. New PET system permits reliable estimates of myocardial blood flow and flow reserve.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Masaya SudaDepartment of Quantum Medical Technology, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa, 920-0942, Ishikawa, Japan. msuda@nms.ac.jp.
Masahisa OnoguchiDepartment of Quantum Medical Technology, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa, 920-0942, Ishikawa, Japan. onoguchi@staff.kanazawa-u.ac.jp.
Takeshi TomiyamaDepartment of Radiology, Nippon Medical School, Tokyo, Japan.
Keiichi IshiharaClinical Imaging Center for Healthcare, Nippon Medical School, Tokyo, Japan.
Naoto TakahashiDepartment of Cardiology, Nippon Medical School, Tokyo, Japan.
Minoru SakuraiClinical Imaging Center for Healthcare, Nippon Medical School, Tokyo, Japan.
Keiichi MatsumotoKyoto College of Medical Science, Nantan, Japan.
Shin-Ichiro KumitaDepartment of Radiology, Nippon Medical School, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aimed to validate the reproducibility of quantitative analysis using time-of-flight (TOF) and conventional PET with (13)N-ammonia ((13)N-NH3). METHODS AND

resultsPhantom images were reconstructed with and without TOF, and recovery coefficients (RCs) and the percent contrast of each sphere over the percent background variability were assessed. In the clinical study, 21 subjects underwent dynamic (13)N-NH3 PET scanning under stress and rest conditions. The dynamic acquisition images and intra- and inter-observer reproducibility of myocardial blood flow (MBF) and coronary flow reserve (CFR) were compared between reconstructions (with and without TOF). In the phantom study, RCs and the percent contrast of each sphere over the percent background variability was improved with TOF. In the clinical study, the noise of blood pool and myocardial images with TOF was less than that without TOF. Territorial and global intra- and inter-observer reproducibility of MBF and CFR values was excellent. Although segmental intra- and inter-observer reproducibility was excellent, there were larger variations in apex and the segment near the right ventricle (RV) without TOF. These variations became inconspicuous with TOF.

conclusionVisual image quality, RCs, and percent contrast over percent background variability with TOF were better than that without TOF. Excellent correlations and good agreements in quantitative values were observed. TOF improved the variation of segmental values.

Indexed as

Blood Flow VelocityCoronary CirculationAmmoniaCoronary VesselsFemaleHumansImage EnhancementMaleMiddle AgedMyocardial Perfusion ImagingNitrogen RadioisotopesObserver VariationPhantoms, ImagingPositron-Emission TomographyAmmoniaNitrogen-13Nitrogen Radioisotopes13N-ammonia (13N-NH3)coronary flow reserve (CFR)Myocardial blood flow (MBF)positron emission tomography (PET)time-of-flight (TOF)

Identifiers

PMID25777781

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.