ArticleDigestive diseases and sciences2015
Suboptimal Bowel Preparation Significantly Impairs Colonoscopic Detection of Non-polypoid Colorectal Neoplasms.
Article in Digestive diseases and sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- A prospective, single-blinded, non-inferiority, randomized controlled study comparing the effectiveness and safety of oral lactulose combined with carbohydrate-containing clear liquids versus 3-L polyethylene glycol electrolyte for colonoscopy bowel preparation.European journal of medical research · 2025Trial
- Lactulose Combined With PEG for Effective and Safe Bowel Preparation Before Colonoscopy: A Meta-Analysis.JGH open : an open access journal of gastroenterology and hepatology · 2025Review
- Innovative schemes of colonoscopy bowel preparation with oral lactulose: Optimizing traditional standards to improve colonoscopy quality.World journal of gastrointestinal endoscopy · 2025Review
- Novel regimen for colonoscopy bowel preparation with oral lactulose: a prospective comparative study.Clinical endoscopy · 2024Article
- A Better Prep School: Does an Interactive Instruction Video Improve Colon Cleanliness?Digestive diseases and sciences · 2022Article
- The Effectiveness and Tolerability of a Very Low-Volume Bowel Preparation for Colonoscopy Compared to Low and High-Volume Polyethylene Glycol-Solutions in the Real-Life Setting.Diagnostics (Basel, Switzerland) · 2022Article
- Metachronous neoplasms in patients with laterally spreading tumours during surveillance.United European gastroenterology journal · 2021Article
- Bowel-cleansing efficacy of the 1L polyethylene glycol-based bowel preparation NER1006 (PLENVU) in patient subgroups in two phase III trials.Therapeutic advances in gastroenterology · 2021Article
- Improved detection of colorectal adenomas by high-quality colon cleansing.Endoscopy international open · 2020Article
- High-quality colon cleansing and multiple neoplasia detection with 1L NER1006 versus mid-volume options: Post hoc analysis of phase 3 clinical trials.Endoscopy international open · 2020Article
- Impact of Colonoscopy Bowel Preparation Quality on Follow-up Interval Recommendations for Average-risk Patients With Normal Screening Colonoscopies: Data From the New Hampshire Colonoscopy Registry.Journal of clinical gastroenterology · 2020Article
- Impact of Inadequate Bowel Cleansing on Colonoscopic Findings in Routine Screening Practice.Clinical and translational gastroenterology · 2020Article
- Water Exchange Versus Split-Dose Bowel Preparation and the ADR: Is WE There Yet?Digestive diseases and sciences · 2018Article
- Inadequate Boston Bowel Preparation Scale scores predict the risk of missed neoplasia on the next colonoscopy.Gastrointestinal endoscopy · 2018Observational
- Efficacy and safety of PICOPREP tailored dosing compared with PICOPREP day-before dosing for colon cleansing: a multi-centric randomised study.Endoscopy international open · 2017Article
- Impact of Colonoscopy Insertion Techniques on Adenoma Detection.Digestive diseases and sciences · 2016Article
- What Can We Do to Optimize Colonoscopy and How Effective Can We Be?Current gastroenterology reports · 2016Review
- Intraprocedural Cleansing for Screening Colonoscopy: Avoiding Brownouts.Digestive diseases and sciences · 2015Article
- Split-dose bowel preparation versus water exchange and adenoma detection rate: have we arrived there yet?Annals of gastroenterologyArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is unclear whether the quality of bowel preparation affects colonoscopic detection of non-polypoid colorectal neoplasms (NP-CRNs).
aimTo evaluate the impact of bowel-cleansing quality on detection of NP-CRNs.
methodsWe performed a retrospective analysis of asymptomatic screening colonoscopy cases after standardized bowel preparation at an academic teaching hospital between June 2011 and May 2013. Primary outcome was a comparison of the adenoma detection rate (ADR) of non-polypoid morphology according to quality of bowel preparation. Secondary outcomes included detection prevalence of non-polypoid adenomas.
resultsOf the enrolled 6097 screening examinations, the preparation quality was rated as adequate (excellent or good) in 5224 (85.7 %), fair in 615 (10.1 %), and poor in 258 (4.2 %) patients. The prevalence of NP-CRNs was 40.5 % (1962/4847) of all CRNs. The overall ADR of non-polypoid morphology was 12.3 % (747/6097) of all colonoscopies, but it significantly differed among participating endoscopists (all P < 0.05). The ADR of non-polypoid morphology was significantly lower with fair- or poor-quality preparation, versus adequate-quality preparation (adjusted odds ratio [aOR] 0.55, 95 % confidence interval [CI] 0.41-0.75; aOR 0.49, 95 % CI 0.30-0.79, respectively). Poor-quality preparation was also associated with impaired detection of polypoid, proximal colon, and sub-centimeter adenomas (all P < 0.05).
conclusionsSuboptimal (fair or poor) bowel preparation significantly impairs colonoscopic detection of NP-CRNs. Given that the prevalence of NP-CRNs is substantial in our average-risk screening cohort, ongoing efforts to improve the preparation quality are practically valuable in increasing the detection of NP-CRNs, thereby improving the efficacy of screening colonoscopies.
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