Evidence map›Paper›PMID 25777180›Full record

ReviewInternational journal of obesity (2005)2015

Maternal obesity and metabolic risk to the offspring: why lifestyle interventions may have not achieved the desired outcomes.

P Catalano, S H deMouzon

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of obesity (2005), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
130citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

130 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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  20. Heavy moms, wheezy kids: how maternal obesity harms breathing in offspring.American journal of respiratory cell and molecular biology · 2026
    Review

70 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

P CatalanoReproductive Biology, Case Western Reserve University, Center for Reproductive Health in the Department of Obstetrics and Gynecology MetroHealth Medical Center, Cleveland, OH, USA.
S H deMouzonReproductive Biology, Case Western Reserve University, Center for Reproductive Health in the Department of Obstetrics and Gynecology MetroHealth Medical Center, Cleveland, OH, USA.

Funding

Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
INSULIN RESISTANCE AND GLUCOSE METABOLISM IN PREGNANCYR01HD022965 · NICHD · CASE WESTERN RESERVE UNIVERSITY · PI CATALANO, PATRICK · 1994 to 2011
$2.3M
INSULIN RESISTANCE AND GLUCOSE METABOLISM IN PREGNANCYR29HD022965 · NICHD · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI CATALANO, PATRICK MICHAEL · 1987 to 1991
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NCATS NIH HHS UL1 TR000439NCATS NIH HHS UL1TR000439NICHD NIH HHS HD-22965-19NICHD NIH HHS R01 HD022965
6 · The paper itself

Abstract

Obesity during pregnancy is associated with an increased risk of short- and long-term metabolic dysfunction in the mother and her offspring. Both higher maternal pregravid body mass index (kg m(-2)) and excessive gestational weight gain (GWG) have been associated with adverse pregnancy outcomes such as gestational diabetes, preeclampsia and fetal adiposity. Multiple lifestyle intervention trials consisting of weight management using various diets, increased physical activity and behavioral modification techniques have been employed to avoid excessive GWG and improve perinatal outcomes. These randomized controlled trials (RCTs) have achieved modest success in decreasing excessive GWG, although the decrease in GWG was often not within the current Institute of Medicine guidelines. RCTs have generally not had any success with decreasing the risk of maternal gestational diabetes (GDM), preeclampsia or excessive fetal growth often referred to as macrosomia. Although the lack of success for these trials has been attributed to lack of statistical power and poor compliance with study protocols, our own research suggests that maternal pregravid and early pregnancy metabolic condition programs early placenta function and gene expression. These alterations in maternal/placental function occur in the first trimester of pregnancy prior to when most intervention trials are initiated. For example, maternal accrural of adipose tissue relies on prior activation of genes controlling lipogenesis and low-grade inflammation in early pregnancy. These metabolic alterations occur prior to any changes in maternal phenotype. Therefore, trials of lifestyle interventions before pregnancy are needed to demonstrate the safety and efficacy for both the mother and her offspring.

Indexed as

AdultBirth WeightBlood GlucoseBody CompositionBody Mass IndexDiabetes, GestationalFemaleHumansMaleMothersObesityPregnancyPregnancy ComplicationsRandomized Controlled Trials as TopicRisk Reduction BehaviorUnited StatesBlood Glucose

Identifiers

PMID25777180
PMCPMC4700513

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.