Observational studyInternational journal of epidemiology2015
High tobacco consumption lowers body weight: a Mendelian randomization study of the Copenhagen General Population Study.
Observational study in International journal of epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 3 of them syntheses that pooled it.
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43 citing papers in PubMed, 3 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Causal effects from tobacco smoking initiation on obesity-related traits: a Mendelian randomization study.International journal of obesity (2005) · 2023Pooled it
- Association of serum leptin and ghrelin levels with smoking status on body weight: a systematic review and meta-analysis.Frontiers in psychiatry · 2023Pooled it
- Body mass index, abdominal fatness, and the risk of sudden cardiac death: a systematic review and dose-response meta-analysis of prospective studies.European journal of epidemiology · 2018Pooled it
- The causal relevance of body mass index in different histological types of lung cancer: A Mendelian randomization study.Scientific reports · 2016Trial
- Body mass index and ampulla of Vater cancer incidence and survival: a cohort study of 1.7 million Norwegians.Hepatobiliary surgery and nutrition · 2026Article
- Prevalence and determinants of metabolic syndrome among Tehran adults: a cross-sectional analysis from the Tehran cohort study (TeCS).Journal of diabetes and metabolic disorders · 2025Article
- High BMI and smoking jointly cause COPD: a Mendelian randomisation study.BMJ open respiratory research · 2025Article
- Factors influencing traditional adiposity indicators and mammary adipocyte size in women with breast cancer.International journal of obesity (2005) · 2025Article
- Impact of socioeconomic status on obesity in older adults: the suppressive effect of social support and sleep quality.BMC geriatrics · 2025Article
- Cannabis, Weight, and Weight-Related Behaviors.Current obesity reports · 2025Review
- The association between body mass index and vulvar and vaginal cancer incidence: findings from a large Norwegian cohort study.Cancer causes & control : CCC · 2025Article
- Body mass index and penile cancer incidence: results from a Norwegian cohort study of 829,081 men.BMC urology · 2024Article
- General or Central Obesity and Mortality Among US Hispanic and Latino Adults.JAMA network open · 2024Article
- Comparison of metabolic syndrome prevalence and characteristics using five different definitions in China: a population-based retrospective study.Frontiers in public health · 2024Article
- Tobacco smoke exacerbates Filifactor alocis pathogenicity.Journal of clinical periodontology · 2023Article
- The prevalence and characteristics of metabolic syndrome according to different definitions in China: a nationwide cross-sectional study, 2012-2015.BMC public health · 2022Article
- How does childhood maltreatment influence cardiovascular disease? A sequential causal mediation analysis.International journal of epidemiology · 2022Article
- Likelihood-based Mendelian randomization analysis with automated instrument selection and horizontal pleiotropic modeling.Science advances · 2022Article
- Association between Thyroid Cancer and Breast Cancer: Two Longitudinal Follow-Up Studies Using a National Health Screening Cohort.Journal of personalized medicine · 2022Article
- Distributions of serum thyroid-stimulating hormone in 2020 thyroid disease-free adults from areas with different iodine levels: a cross-sectional survey in China.Journal of endocrinological investigation · 2021Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundConflicting evidence has been found regarding the association between high tobacco consumption and body weight among smokers. We tested the hypothesis that high tobacco consumption is causally associated with low body weight.
methodsWe conducted a Mendelian randomization study with a genetic variant in CHRNA3 (rs1051730) as proxy for high tobacco consumption. The cohort consisted of 80,342 participants from the Copenhagen General Population Study, with details on body weight, smoking habits and CHRNA3 genotype, including 15,220 current smokers.
resultsIn observational analyses, high tobacco consumption was associated with high body weight, body mass index, waist circumference, hip circumference and waist-hip ratio. In multivariable adjusted models a 1-cigarette/day higher tobacco consumption was associated with 0.05 kg (95% confidence interval 0.02; 0.08) higher body weight, 0.02 kg/m(2) (0.01; 0.02) higher body mass index, 0.10 cm (0.07; 0.12) higher waist circumference and 0.02 cm (0.001; 0.03) higher hip circumference. In contrast, the per-allele increase inCHRNA3 rs1051730 associated with high tobacco consumption was associated with 0.59 kg (0.96; 0.22) lower body weight, 0.23 kg/m(2) (0.33; 0.13) lower body mass index, 0.32 cm (0.74; 0.003) lower waist circumference and 0.45 cm (0.66; 0.24) lower hip circumference. No association was found between tobacco consumption and waist-hip ratio in genetic analysis, or among CHRNA3 genotype and any of the outcome variables in former or never smokers.
conclusionsHigh tobacco consumption causes lower body weight among current smokers. However, smoking does not seem to affect body shape or fat distribution causally. The lack of association between CHRNA3 genotype and body weight among former smokers and never smokers favours smoking as the causal factor for the observed associations.
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