Evidence map›Paper›PMID 25776990›Full record

ReviewImmunology and cell biology2015

Long noncoding RNAs: a potent source of regulation in immunity and disease.

Albert D Yu, Zichen Wang, Kevin V Morris

Open access · bronzeAbstract readReview
PubMed Publisher
In one paragraph

Review in Immunology and cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. The lncRNA Fer1L4 is an adverse prognostic parameter in clear-cell renal-cell carcinoma.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2020
    Article
  11. Role of long non-coding RNAs (LncRNAs) in multiple sclerosis: a brief review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
    Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Albert D YuBiotechnology and Biomedical Sciences, The University of New South Wales, Sydney, New South Wales, Australia.
Zichen WangBiotechnology and Biomedical Sciences, The University of New South Wales, Sydney, New South Wales, Australia.
Kevin V Morris1] Biotechnology and Biomedical Sciences, The University of New South Wales, Sydney, New South Wales, Australia [2] Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.
UNSW Sydney · AUScripps Research Institute · US

Funding

Targeted Delivery Vechicles for OligonucleotidesP01AI099783 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI AKKINA, RAMESH · 2012 to 2016
$7.4M
6 · The paper itself

Abstract

The discovery of functional long noncoding RNAs (lncRNAs) coupled with the ever-increasing accessibility of genomic and transcriptomic technology has led to an explosion of functional and mechanistic investigation and discovery into what was once dismissed as junk DNA. Over the past decade, a significant number of lncRNAs have been found to be involved in a diverse array of processes: from epigenetic modulation, both repressive and activating; to protein scaffolding; to miRNA sequestration; to competitive inhibition; and more. The broad character of these mechanisms means that lncRNAs have the potential for regulation across all biological processes-not least of which are immunity and disease. A number of lncRNAs operating within these two contexts have already been identified and characterized, but untold more remain yet to be discovered. This review aims to provide an overview of the current state of research on lncRNAs involved in immune modulation and disease, with an emphasis on their mechanism and discovery.

Indexed as

Epigenesis, GeneticImmunomodulationAnimalsAntibody DiversityB-LymphocytesHumansImmunityRNA, Long NoncodingRNA, Long Noncoding

Identifiers

PMID25776990
OpenAlexW1999147414

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.