ArticleMetabolic brain disease2015
Treatment with IL-10 producing B cells in combination with E2 ameliorates EAE severity and decreases CNS inflammation in B cell-deficient mice.
Article in Metabolic brain disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- CRTH2 is critical for IL-1β-producing B cells during experimental autoimmune encephalomyelitis in mice via p38 signaling.Journal of neuroinflammation · 2025Article
- IRAK-M suppresses the activation of microglial NLRP3 inflammasome and GSDMD-mediated pyroptosis through inhibiting IRAK1 phosphorylation during experimental autoimmune encephalomyelitis.Cell death & disease · 2023Article
- PD-L1 is required for estrogen-induced protection against severe EAE in IL-10 deficient miceMetabolic brain disease · 2023Article
- Article
- Toll-Like Receptor Signaling and Immune Regulatory Lymphocytes in Periodontal Disease.International journal of molecular sciences · 2020Review
- Estrogen-induced compensatory mechanisms protect IL-10-deficient mice from developing EAE.Journal of neuroinflammation · 2019Article
- Protective effects ofIranian journal of basic medical sciences · 2019Article
- Antibiotics protect against EAE by increasing regulatory and anti-inflammatory cells.Metabolic brain disease · 2018Article
- Reduced peripheral blood regulatory B cell levels are not associated with the Expanded Disability Status Scale score in multiple sclerosis.The Journal of international medical research · 2018Article
- B Regulatory Cells: Players in Pregnancy and Early Life.International journal of molecular sciences · 2018Review
- Regulatory B cells in experimental stroke.Immunology · 2018Review
- MicroRNAs: Roles in Regulating Neuroinflammation.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2018Article
- Estrogen protection against EAE modulates the microbiota and mucosal-associated regulatory cells.Journal of neuroimmunology · 2017Article
- Sex differences in regulatory cells in experimental stroke.Cellular immunology · 2017Article
- Novel feedback loop between M2 macrophages/microglia and regulatory B cells in estrogen-protected EAE mice.Journal of neuroimmunology · 2017Article
- Regulatory B Cells in Pregnancy: Lessons from Autoimmunity, Graft Tolerance, and Cancer.Frontiers in immunology · 2017Review
- Estrogens, Neuroinflammation, and Neurodegeneration.Endocrine reviews · 2016Review
- Role of regulatory b cells in neuroimmunologic disorders.Journal of neuroscience research · 2016Review
- Estrogen induces multiple regulatory B cell subtypes and promotes M2 microglia and neuroprotection during experimental autoimmune encephalomyelitis.Journal of neuroimmunology · 2016Article
- The role of hormones in the pathogenesis of psoriasis vulgaris.Clujul medical (1957) · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Clinical improvement during pregnancy in multiple sclerosis (MS) patients suggests that sex hormones exert potent regulatory effects on autoimmune function. Our previous studies demonstrated that estrogen- (17β-estradiol; E2) mediated protection against experimental autoimmune encephalomyelitis (EAE), a mouse model for MS, hinges on the B cells, leading to elevated numbers of IL-10 secreting CD1d(hi)CD5(+) B regulatory cells (Bregs) in wild type mice. Our data show that co-administration of E2 and IL-10(+) B cells ameliorates EAE disease severity and limits CNS infiltrating leukocytes in B cell deficient mice. Additionally, treatment with E2 and Bregs reduces demyelination and dramatically decreases the proportion of CD11b(+)CD45(hi) activated microglia/macrophages found in the CNS of immunized animals compared to vehicle, E2 or Breg cells alone. Furthermore, mice given E2 and Bregs exhibit increased numbers of peripheral programmed death-1 positive CD4(+)Foxp3(+) regulatory T cells (Tregs) and up-regulation of programmed death receptor-ligand-1 and CD80 expression on monocytes. Our study suggests IL-10 producing Bregs have powerful therapeutic potential as an agent against EAE when augmented with E2 treatment.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.