ArticleImmunology and cell biology2015
Human thymic epithelial primary cells produce exosomes carrying tissue-restricted antigens.
Article in Immunology and cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 76 citations in OpenAlex.
- Exosome-enabled bone defect repair: mechanistic foundations, bioengineered delivery, and artificial intelligence-driven translation.Journal of nanobiotechnology · 2026Review
- Hydrogel-Based Extracellular Vesicle Isolation Method from Various Biological Solutions.ACS applied bio materials · 2026Article
- Bioengineered extracellular vesicles: The path to precision medicine in liver diseases.Liver research (Beijing, China) · 2025Review
- Research Progress on Using Nanoparticles to Enhance the Efficacy of Drug Therapy for Chronic Mountain Sickness.Pharmaceutics · 2024Review
- Emerging Cancer Immunotherapies: Cutting-Edge Advances and Innovations in Development.Medical sciences (Basel, Switzerland) · 2024Review
- Extracellular Vesicles and Immune System Function: Exploring Novel Approaches to Colorectal Cancer Immunotherapy.Biomedicines · 2024Review
- CellRank 2: unified fate mapping in multiview single-cell data.Nature methods · 2024Article
- The 'communicatome' of pregnancy: spotlight on cellular and extravesicular chimerism.EMBO molecular medicine · 2024Review
- Cell Type-Specific Extracellular Vesicles and Their Impact on Health and Disease.International journal of molecular sciences · 2024Review
- Role of Extracellular Vesicles in Immunity and Host Defense.Immunological investigations · 2024Review
- Comparative Analyses of Human Exosome Proteomes.The protein journal · 2023Article
- The roles of extracellular vesicles in the immune system.Nature reviews. Immunology · 2023Review
- Complex interactions of cellular players in chronic Graft-versus-Host Disease.Frontiers in immunology · 2023Review
- Thymoquinone-loaded mesenchymal stem cell-derived exosome as an efficient nano-system against breast cancer cells.Iranian journal of basic medical sciences · 2022Article
- Human stem cell-derived thymic epithelial cells enhance human T-cell development in a xenogeneic thymus.The Journal of allergy and clinical immunology · 2022Article
- The Landscape of Nanovectors for Modulation in Cancer Immunotherapy.Pharmaceutics · 2022Review
- Review
- Mechanisms of Direct and Indirect Presentation of Self-Antigens in the Thymus.Frontiers in immunology · 2022Review
- Key Factors for Thymic Function and Development.Frontiers in immunology · 2022Review
- Epigenetic modifications in thymic epithelial cells: an evolutionary perspective for thymus atrophy.Clinical epigenetics · 2021Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exosomes are nano-sized vesicles released by cells into the extracellular space and have been shown to be present in thymic tissue both in mice and in humans. The source of thymic exosomes is however still an enigma and hence it is not known whether thymic epithelial cells (TECs) are able to produce exosomes. In this work, we have cultured human TECs and isolated exosomes. These exosomes carry tissue-restricted antigens (TRAs), for example, myelin basic protein and desmoglein 3. The presence of TRAs indicates a possible role for thymic epithelium-derived exosomes in the selection process of thymocytes. The key contribution of these exosomes could be to disseminate self-antigens from the thymic epithelia, thus making them more accessible to the pool of maturing thymocytes. This would increase the coverage of TRAs within the thymus, and facilitate the process of positive and negative selection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.