ArticleInfection and immunity2015
The omentum is a site of protective IgM production during intracellular bacterial infection.
Article in Infection and immunity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Know Your ABCs: Discovery, Differentiation, and Targeting of T-Bet+ B Cells.Immunological reviews · 2025Review
- Review
- Pericardial and mediastinal fat-associated lymphoid clusters are rapidly activated in an alkane-induced model of systemic lupus erythematosus.Discovery immunology · 2023Article
- T-betJournal of immunology (Baltimore, Md. : 1950) · 2022Article
- Specialized immune responses in the peritoneal cavity and omentum.Journal of leukocyte biology · 2021Review
- The Obesity Paradox Predicts the Second Wave of COVID-19 to Be Severe in Western Countries.International journal of environmental research and public health · 2021Article
- Covid-19: Fat, Obesity, Inflammation, Ethnicity, and Sex Differences.Pathogens (Basel, Switzerland) · 2020Article
- Resident Memory B Cells.Viral immunology · 2020Review
- The Greater Omentum-A Vibrant and Enigmatic Immunologic Organ Involved in Injury and Infection Resolution.Shock (Augusta, Ga.) · 2020Review
- 2019 Russell Ross Memorial Lecture in Vascular Biology: B Lymphocyte-Mediated Protective Immunity in Atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2020Article
- Specific Biological Features of Adipose Tissue, and Their Impact on HIV Persistence.Frontiers in microbiology · 2019Review
- ILC2 Orchestration of Local Immune Function in Adipose Tissue.Frontiers in immunology · 2019Review
- White Adipose Tissue Is a Reservoir for Memory T Cells and Promotes Protective Memory Responses to Infection.Immunity · 2017Article
- Patient-derived xenografts of low-grade B-cell lymphomas demonstrate roles of the tumor microenvironment.Blood advances · 2017Article
- Immunological Functions of the Omentum.Trends in immunology · 2017Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
Infection of mice with the bacterium Ehrlichia muris elicits a protective T cell-independent (TI) IgM response mediated primarily by a population of CD11c-expressing plasmablasts in the spleen. Although splenic marginal zone (MZ) B cells are considered to be important for TI responses to blood-borne pathogens, MZ B cells were not responsible for generating plasmablasts in response to Ehrlichia muris. Moreover, antigen-specific serum IgM was decreased only modestly in splenectomized mice and in mice that lacked spleen, lymph nodes, and Peyer's patches (SLP mice). Both splenectomized and SLP mice were protected against lethal ehrlichial challenge infection. Moreover, we found a high frequency of Ehrlichia-specific plasmablasts in the omentum of both conventional and SLP mice. Omental plasmablasts elicited during Ehrlichia infection lacked expression of CD138 but expressed CD11c in a manner similar to that of their splenic counterparts. Selective ablation of CD11c-expressing B cells nearly eliminated the omental Ehrlichia-specific plasmablasts and reduced antigen-specific serum IgM, identifying the omental B cells as a source of IgM production in the SLP mice. Generation of the omental plasmablasts was route dependent, as they were detected following peritoneal infection but not following intravenous infection. Our data identify the omentum as an important auxiliary site of IgM production during intracellular bacterial infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.