Evidence map›Paper›PMID 25776188›Full record

ArticleJournal of vascular surgery2015

Race as a predictor of delay from diagnosis to endarterectomy in clinically significant carotid stenosis.

Eric S Wise, Travis R Ladner, Jun Song, Susan S Eagle, J Mocco, Justine E Wergin, Kyle M Hocking, Colleen M Brophy

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Journal of vascular surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Eric S WiseDepartment of Surgery, Vanderbilt University Medical Center, Nashville, Tenn. Electronic address: eric.s.wise@vanderbilt.edu.
Travis R LadnerVanderbilt University School of Medicine, Nashville, Tenn.
Jun SongUniversity of Tennessee Health Sciences Center, Memphis, Tenn.
Susan S EagleDepartment of Cardiothoracic Anesthesiology, Vanderbilt University Medical Center, Nashville, Tenn.
J MoccoDepartment of Neurosurgery, Vanderbilt University Medical Center, Nashville, Tenn.
Justine E WerginVanderbilt University School of Medicine, Nashville, Tenn.
Kyle M HockingDepartment of Surgery, Vanderbilt University Medical Center, Nashville, Tenn; Department of Biomedical Engineering, Vanderbilt University, Nashville, Tenn.
Colleen M BrophyDepartment of Surgery, Vanderbilt University Medical Center, Nashville, Tenn; Department of Vascular Surgery, VA Tennessee Valley Healthcare System, Nashville, Tenn.
Vanderbilt University · USVanderbilt University Medical Center · USUniversity of Tennessee Health Science Center · USVA Tennessee Valley Healthcare System · US

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
NCATS NIH HHS UL1 TR000445
6 · The paper itself

Abstract

objectivePrompt carotid endarterectomy (CEA) in clinically significant carotid stenosis is important in the prevention of neurologic sequelae. The greatest benefit from surgery is obtained by prompt revascularization on diagnosis. It has been demonstrated that black patients both receive CEA less frequently than white patients do and experience worse postoperative outcomes. We sought to test our hypothesis that black race is an independent risk factor for a prolonged time from sonographic diagnosis of carotid stenosis warranting surgery to the day of operation (TDO).

methodsFrom 1998 to 2013 at a single institution, 166 CEA patients were retrospectively reviewed using Synthetic Derivative, a de-identified electronic medical record. Factors potentially affecting TDO, including demographics, preoperative cardiac stress testing, degree of stenosis, smoking status, and comorbidities, were noted. Multivariate analysis was performed on variables that trended with prolonged TDO on univariate analysis (P < .10) to determine independent (P < .05) predictors of TDO. Subgroup analyses were further performed on the symptomatic and asymptomatic stenosis cohorts.

resultsThere were 32 black patients and 134 white patients studied; the mean TDO was 78 ± 17 days vs 33 ± 3 days, respectively (P < .001). In addition to the need for preoperative cardiac stress testing, black race was the only variable that demonstrated a trend with (P < .10) or was an independent risk factor for (P < .05) prolonged TDO among all patients (B = 42 days; P < .001) and within the symptomatic (B = 35 days; P = .08) and asymptomatic (B = 35 days; P = .003) cohorts. On Kaplan-Meier analysis, black patients in each stratum of symptomatology (all, symptomatic, and asymptomatic patients) experienced prolonged TDO (log-rank, P < .03 for all three groups).

conclusionsBlack race is a risk factor for a temporal delay in CEA for carotid stenosis. Awareness of this disparity may help surgeons avoid undesirable delays in operation for their black patients.

Indexed as

Black or African AmericanEndarterectomy, CarotidTime-to-TreatmentAgedCarotid StenosisElectronic Health RecordsFemaleHealthcare DisparitiesHumansKaplan-Meier EstimateLinear ModelsMaleMultivariate AnalysisPredictive Value of TestsRetrospective StudiesRisk Factors

Identifiers

PMID25776188
PMCPMC4484302
OpenAlexW2085878518

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.