ArticleProceedings of the National Academy of Sciences of the United States of America2015
Facilitation of fear extinction by novelty depends on dopamine acting on D1-subtype dopamine receptors in hippocampus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- A translational perspective on neural circuits of fear extinction: Current promises and challenges.Neurobiology of learning and memory · 2018Pooled it
- DNA methylation changes following narrative exposure therapy in a randomized controlled trial with female former child soldiers.Scientific reports · 2021Trial
- Augmenting extinction with counterconditioning strengthens and sustains neural safety representations in PTSD.Translational psychiatry · 2026Article
- Predictors of the Effectiveness of Psychedelics in Treating Depression-A Scoping Review.International journal of molecular sciences · 2026Article
- Dopamine: The Essential Bridge Mediating Obstructive Sleep Apnea and Hippocampus-Dependent Learning and Memory Impairments.World journal of otorhinolaryngology - head and neck surgery · 2026Review
- A behavioral tagging account of kinase contribution to memory formation after spaced aversive training.iScience · 2023Article
- Locus coeruleus input-modulated reactivation of dentate gyrus opioid-withdrawal engrams promotes extinction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Tag and capture: how salient experiences target and rescue nearby events in memory.Trends in cognitive sciences · 2022Review
- Dopaminergic regulation of hippocampal plasticity, learning, and memory.Frontiers in behavioral neuroscience · 2022Review
- The role of hippocampus in memory reactivation: an implication for a therapeutic target against opioid use disorder.Current addiction reports · 2022Review
- Gender dimorphic effect of dopamine D2 and muscarinic cholinergic receptors on memory retrieval.Psychopharmacology · 2021Article
- Elevated activity in the dorsal dentate gyrus reduces expression of fear memory after fear extinction training.Journal of psychiatry & neuroscience : JPN · 2021Article
- Dopamine: The Neuromodulator of Long-Term Synaptic Plasticity, Reward and Movement Control.Cells · 2021Review
- Contribution of D1R-expressing neurons of the dorsal dentate gyrus and CaNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Behavioral tagging underlies memory reconsolidation.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Dopamine: from prediction error to psychotherapy.Translational psychiatry · 2020Review
- Dopaminergic Plasticity in the Bilateral Hippocampus Following Threat Reversal in Humans.Scientific reports · 2020Article
- Modulating reconsolidation and extinction to regulate drug reward memory.The European journal of neuroscience · 2019Review
- Sex differences in fear extinction.Neuroscience and biobehavioral reviews · 2019Review
- Maternal Deprivation Induces Memory Deficits That Are Reduced by One Aerobic Exercise Shot Performed after the Learning Session.Neural plasticity · 2019Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extinction is the learned inhibition of retrieval. Recently it was shown that a brief exposure to a novel environment enhances the extinction of contextual fear in rats, an effect explainable by a synaptic tagging-and-capture process. Here we examine whether this also happens with the extinction of another fear-motivated task, inhibitory avoidance (IA), and whether it depends on dopamine acting on D1 or D5 receptors. Rats were trained first in IA and then in extinction of this task. The retention of extinction was measured 24 h later. A 5-min exposure to a novel environment 30 min before extinction training enhanced its retention. Right after exposure to the novelty, animals were given bilateral intrahippocampal infusions of vehicle (VEH), of the protein synthesis inhibitor anisomycin, of the D1/D5 dopaminergic antagonist SCH23390, of the PKA inhibitor Rp-cAMP or of the PKC inhibitor Gö6976, and of the PKA stimulator Sp-cAMP or of the PKC stimulator PMA. The novelty increased hippocampal dopamine levels and facilitated the extinction, which was inhibited by intrahippocampal protein synthesis inhibitor anisomysin, D1/D5 dopaminerdic antagonist SCH23390, or PKA inhibitor Rp-cAMP and unaffected by PKC inhibitor Gö6976; additionally, the hippocampal infusion of PKA stimulator Sp-cAMP reverts the effect of D1/D5 dopaminergic antagonist SCH 23390, but the infusion of PKC stimulator PMA does not. The results attest to the generality of the novelty effect on fear extinction, suggest that it relies on synaptic tagging and capture, and show that it depends on hippocampal dopamine D1 but not D5 receptors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.