ArticleProceedings of the National Academy of Sciences of the United States of America2015
Regional inactivations of primate ventral prefrontal cortex reveal two distinct mechanisms underlying negative bias in decision making.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03958903 (Investigations of Amygdala Function Using Neurophysiological Recording and Stimulation), which is not on this map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigations of Amygdala Function Using Neurophysiological Recording and Stimulation
Who cites it
29 citing papers in PubMed, 52 citations in OpenAlex.
- Amygdala Lesions Reduce Anxiety-like Behavior in a Human Benzodiazepine-Sensitive Approach-Avoidance Conflict Test.Biological psychiatry · 2017Trial
- Home-cage pharmacology in marmosets: behavioral effects of scopolamine.Psychopharmacology · 2026Article
- Scopolamine induced learning deficit in marmosets.Research square · 2025Article
- Scopolamine induced learning deficit in marmosets.bioRxiv : the preprint server for biology · 2025Article
- Cingulate microstimulation induces negative decision-making via reduced top-down influence on primate fronto-cingulo-striatal network.Nature communications · 2024Article
- A theory of the neural mechanisms underlying negative cognitive bias in major depression.Frontiers in psychiatry · 2024Article
- Altered resting-state cerebral blood flow and functional connectivity mediate suicidal ideation in major depressive disorder.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Differential Effects of the Inactivation of Anterior and Posterior Orbitofrontal Cortex on Affective Responses to Proximal and Distal Threat, and Reward Anticipation in the Common Marmoset.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- The Role of the Dorsal-Lateral Prefrontal Cortex in Reward Sensitivity During Approach-Avoidance Conflict.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Prefrontal cortex and depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Understanding them to understand ourselves: The importance of NHP research for translational neuroscience.Current research in neurobiology · 2022Article
- Causal Evidence for Induction of Pessimistic Decision-Making in Primates by the Network of Frontal Cortex and Striosomes.Frontiers in neuroscience · 2021Article
- Ventromedial prefrontal area 14 provides opposing regulation of threat and reward-elicited responses in the common marmoset.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Approach-Avoidance Conflict in Major Depressive Disorder: Congruent Neural Findings in Humans and Nonhuman Primates.Biological psychiatry · 2020Article
- Hippocampal Interaction With Area 25, but not Area 32, Regulates Marmoset Approach-Avoidance Behavior.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- A Focus on the Functions of Area 25.Brain sciences · 2019Review
- Selective Role of the Putamen in Serial Reversal Learning in the Marmoset.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Ventral striatum's role in learning from gains and losses.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Behavioral and neurobiological mechanisms of punishment: implications for psychiatric disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Review
- Inactivation of the Ventrolateral Orbitofrontal Cortex Impairs Flexible Use of Safety Signals.Neuroscience · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
Dysregulation of the orbitofrontal and ventrolateral prefrontal cortices is implicated in anxiety and mood disorders, but the specific contributions of each region are unknown, including how they gate the impact of threat on decision making. To address this, the effects of GABAergic inactivation of these regions were studied in marmoset monkeys performing an instrumental approach-avoidance decision-making task that is sensitive to changes in anxiety. Inactivation of either region induced a negative bias away from punishment that could be ameliorated with anxiolytic treatment. However, whereas the effects of ventrolateral prefrontal cortex inactivation on punishment avoidance were seen immediately, those of orbitofrontal cortex inactivation were delayed and their expression was dependent upon an amygdala-anterior hippocampal circuit. We propose that these negative biases result from deficits in attentional control and punishment prediction, respectively, and that they provide the basis for understanding how distinct regional prefrontal dysregulation contributes to the heterogeneity of anxiety disorders with implications for cognitive-behavioral treatment strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.