ArticleProceedings of the National Academy of Sciences of the United States of America2015
Identification of FOXO targets that generate diverse features of the diapause phenotype in the mosquito Culex pipiens.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed, 137 citations in OpenAlex.
- The clock gene cycle synchronizes circadian metabolic oscillations uniquely in reproductively active Culex pipiens females.npj metabolic health and disease · 2026Article
- Early photoperiodic cues modulate capacity for adult cold tolerance in the yellow fever mosquito Aedes aegypti.The Journal of experimental biology · 2026Article
- Lipid Metabolism in Diapause.Advances in experimental medicine and biology · 2026Review
- Environmental Factors That Regulate Mosquito Physiology and Behavior.Annual review of entomology · 2026Review
- The microRNA pathway regulates obligatory aestivation in the cabbage stem flea beetle Psylliodes chrysocephala.Communications biology · 2025Article
- The cycle gene is essential for both daily responses and seasonal reproduction in the Northern house mosquito, Culex pipiens.Scientific reports · 2025Article
- Using diapause as a platform to understand the biology of dormancy.Open biology · 2025Review
- Noncanonical action of circadian clock genes controls winter diapause entry via the NuA4/TIP60 complex inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Vertical transmission in field-caught mosquitoes identifies a mechanism for the establishment of Usutu virus in a temperate country.Scientific reports · 2025Article
- Article
- Diapause and Anoxia-Induced Quiescence Are Unique States in Embryos of the Annual Killifish,Biomolecules · 2025Article
- A Head-Specific Transcriptomic Study Reveals Key Regulatory Pathways for Winter Diapause in the Mosquito Culex pipiens.Archives of insect biochemistry and physiology · 2025Article
- Article
- Genome-wide identification of PAR domain protein 1 (PDP1) targets through ChIP-seq reveals the regulation of diapause-specific characteristics in Culex pipiens.Insect molecular biology · 2024Article
- The diapausing mosquito Culex pipiens exhibits reduced levels of H3K27me2 in the fat body.Insect molecular biology · 2024Article
- Genome-wide analysis reveals transcriptional and translational changes during diapause of the Asian corn borer (Ostrinia furnacalis).BMC biology · 2024Article
- Transcription profiling reveals tissue-specific metabolic pathways in the fat body and ovary of the diapausing mosquito Culex pipiens.Comparative biochemistry and physiology. Part D, Genomics & proteomics · 2024Article
- Forecasting West Nile Virus With Graph Neural Networks: Harnessing Spatial Dependence in Irregularly Sampled Geospatial Data.GeoHealth · 2024Article
- Arthropod-Borne Viruses of Human and Animal Importance: Overwintering in Temperate Regions of Europe during an Era of Climate Change.Microorganisms · 2024Review
- Genome-wide profiles of H3K9me3, H3K27me3 modifications, and DNA methylation during diapause of Asian corn borer (Genome research · 2024Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insulin and juvenile hormone signaling direct entry of the mosquito Culex pipiens into its overwintering adult diapause, and these two critical signaling pathways appear to do so by converging on the regulation of forkhead transcription factor (FOXO). Diapause is a complex phenotype, and FOXO emerges as a prime candidate for activating many of the diverse physiological pathways that generate the diapause phenotype. Here, we used ChIP sequencing to identify direct targets of FOXO. The nearest gene in a 10-kb region surrounding a predicted binding site was extracted for each binding site, resulting in a dataset containing genes potentially regulated by FOXO. By selecting candidate genes based on their functional relevance to diapause, we identified five gene categories of potential interest, including stress tolerance, metabolic pathways, lifespan extension, cell cycle and growth regulation, and circadian rhythms. Twelve targets were prioritized for further analysis, 10 of which were validated by ChIP-quantitative PCR and quantitative real-time PCR. These 10 genes activated by FOXO are highly up-regulated during diapause and are thus strong candidates for implementation of the diapause syndrome.
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