ArticleProceedings of the National Academy of Sciences of the United States of America2015
Microdroplet fusion mass spectrometry for fast reaction kinetics.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
What it found
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Who cites it
65 citing papers in PubMed, 260 citations in OpenAlex.
- Rapid spontaneous generation of organosulfur from inorganic sulfur in atmospheric microdroplets.Nature communications · 2026Article
- Enhancement of Esterification Reaction Rates in Solvent-Free Aerosol Droplets.Journal of the American Chemical Society · 2026Article
- Droplet-on-demand mass spectrometry reveals curvature-dependent interfacial reactivity in aqueous microdroplets.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Liquid Crystal-Driven Chemical Feeding Accelerates Condensation Reactions in Droplet Microreactors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Microdroplet Mass Spectrometry Enables Rapid and Sensitive Measurement of Glucose Homeostasis for Elucidating Mechanism of Drug Action.Analytical chemistry · 2025Article
- Catalyst-free Ullmann coupling in aqueous microdroplets.Nature communications · 2025Article
- Ultrafast Microdroplet Digestion of Antibodies with Fc-Silencing Mutations.Analytical chemistry · 2025Article
- Humidity drives spontaneous OH oxidation of organic particles.Science advances · 2025Article
- Interfacial electromigration for accelerated reactions.Analytica chimica acta · 2025Article
- Detection of Retinoic Acid in Cosmetics Using Reactive Paper Spray Ionization Mass Spectrometry.Molecules (Basel, Switzerland) · 2025Article
- Deciphering the mechanism of hydrogen peroxide formation in ultrasound-mediated water-in-oil microdroplets.Chemical science · 2025Article
- Spraying of water microdroplets forms luminescence and causes chemical reactions in surrounding gas.Science advances · 2025Article
- Rapid and Sensitive Chemical Analysis of Individual Picolitre Droplets by Mass Spectrometry.Analytical chemistry · 2025Article
- Demethylation C-C coupling reaction facilitated by the repulsive Coulomb force between two cations.Nature communications · 2024Article
- Surfactant Partitioning Dynamics in Freshly Generated Aerosol Droplets.Journal of the American Chemical Society · 2024Article
- Accelerating protein aggregation and amyloid fibrillation for rapid inhibitor screening.Chemical science · 2024Article
- Enhanced Compound Analysis Using Reactive Paper Spray Mass Spectrometry: Leveraging Schiff Base Reaction for Amino Acid Detection.Analytical chemistry · 2024Article
- Spontaneous Recycling of Electrosprayed Sample by Retrograde Motion of Microdroplets.Journal of the American Society for Mass Spectrometry · 2024Article
- Unlocking the potential of 3D printed microfluidics for mass spectrometry analysis using liquid infused surfaces.Analytica chimica acta · 2023Article
- Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
We investigated the fusion of high-speed liquid droplets as a way to record the kinetics of liquid-phase chemical reactions on the order of microseconds. Two streams of micrometer-size droplets collide with one another. The droplets that fused (13 μm in diameter) at the intersection of the two streams entered the heated capillary inlet of a mass spectrometer. The mass spectrum was recorded as a function of the distance x between the mass spectrometer inlet and the droplet fusion center. Fused droplet trajectories were imaged with a high-speed camera, revealing that the droplet fusion occurred approximately within a 500-μm radius from the droplet fusion center and both the size and the speed of the fused droplets remained relatively constant as they traveled from the droplet fusion center to the mass spectrometer inlet. Evidence is presented that the reaction effectively stops upon entering the heated inlet of the mass spectrometer. Thus, the reaction time was proportional to x and could be measured and manipulated by controlling the distance x. Kinetic studies were carried out in fused water droplets for acid-induced unfolding of cytochrome c and hydrogen-deuterium exchange in bradykinin. The kinetics of the former revealed the slowing of the unfolding rates at the early stage of the reaction within 50 μs. The hydrogen-deuterium exchange revealed the existence of two distinct populations with fast and slow exchange rates. These studies demonstrated the power of this technique to detect reaction intermediates in fused liquid droplets with microsecond temporal resolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.