ArticleProceedings of the National Academy of Sciences of the United States of America2015
Electrical synapses connect a network of gonadotropin releasing hormone neurons in a cichlid fish.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 49 citations in OpenAlex.
- The neuroendocrine basis for parental care in teleost fish.Current opinion in neurobiology · 2026Review
- Cichlid fish as a model for understanding social dysfunction.Current opinion in neurobiology · 2026Review
- Cell-type-specific architecture of the hypothalamus in a socially plastic vertebrate.bioRxiv : the preprint server for biology · 2026Article
- Expression of novel androgen receptors in three GnRH neuron subtypes in the cichlid brain.Journal of neuroendocrinology · 2024Article
- The Transcriptome Characterization of the Hypothalamus and the Identification of Key Genes during Sexual Maturation in Goats.International journal of molecular sciences · 2024Article
- Expression of novel androgen receptors in three GnRH neuron subtypes in the cichlid brain.bioRxiv : the preprint server for biology · 2024Article
- Genome editing in East African cichlids and tilapias: state-of-the-art and future directions.Open biology · 2023Review
- Gene duplication of C-type natriuretic peptide-4 (CNP4) in teleost lineage elicits subfunctionalization of ancestral CNP.Cell and tissue research · 2022Article
- Manipulation of the Tyrosinase gene permits improved CRISPR/Cas editing and neural imaging in cichlid fish.Scientific reports · 2021Article
- Morphological Evidence for Functional Crosstalk Between Multiple GnRH Systems in the Male Tilapia,Frontiers in endocrinology · 2020Article
- Mechanistic target of rapamycin (mTOR) implicated in plasticity of the reproductive axis during social status transitions.General and comparative endocrinology · 2019Article
- Genome-wide effects of social status on DNA methylation in the brain of a cichlid fish, Astatotilapia burtoni.BMC genomics · 2019Article
- Fgf3 is crucial for the generation of monoaminergic cerebrospinal fluid contacting cells in zebrafish.Biology open · 2019Article
- Protein Kinase C Enhances Electrical Synaptic Transmission by Acting on Junctional and Postsynaptic CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- The Value of Comparative Animal Research: Krogh's Principle Facilitates Scientific Discoveries.Policy insights from the behavioral and brain sciences · 2018Article
- Cognitive skills and the evolution of social systems.The Journal of experimental biology · 2017Review
- Dopaminergic inhibition of gonadotropin-releasing hormone neurons in the cichlid fish Astatotilapia burtoni.The Journal of experimental biology · 2016Article
- Changes of Sexual Behaviors in Rapamycin-injected Cichlid FishDevelopment & reproduction · 2016Article
- Timing reproduction in teleost fish: cues and mechanisms.Current opinion in neurobiology · 2016Review
- A Neural Basis for Control of Cichlid Female Reproductive Behavior by Prostaglandin F2α.Current biology : CB · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Initiating and regulating vertebrate reproduction requires pulsatile release of gonadotropin-releasing hormone (GnRH1) from the hypothalamus. Coordinated GnRH1 release, not simply elevated absolute levels, effects the release of pituitary gonadotropins that drive steroid production in the gonads. However, the mechanisms underlying synchronization of GnRH1 neurons are unknown. Control of synchronicity by gap junctions between GnRH1 neurons has been proposed but not previously found. We recorded simultaneously from pairs of transgenically labeled GnRH1 neurons in adult male Astatotilapia burtoni cichlid fish. We report that GnRH1 neurons are strongly and uniformly interconnected by electrical synapses that can drive spiking in connected cells and can be reversibly blocked by meclofenamic acid. Our results suggest that electrical synapses could promote coordinated spike firing in a cellular assemblage of GnRH1 neurons to produce the pulsatile output necessary for activation of the pituitary and reproduction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.