Evidence map›Paper›PMID 25775427›Full record

ArticlePloS one2015

Cultivation and differentiation change nuclear localization of chromosome centromeres in human mesenchymal stem cells.

Yana I Voldgorn, Elmira P Adilgereeva, Evgeny D Nekrasov, Alexander V Lavrov

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Yana I VoldgornFederal State Budgetary Institution «Research Centre for Medical Genetics» of the Russian Academy of Medical Sciences, Russia, 115478, Moscow, Moskvorechie, 1; State Budgetary Educational Institution of Higher Professional Education "Russian National Research Medical University named after N.I. Pirogov" of Ministry of Health of the Russian Federation, Russia, 117997, Moscow, Ostrovityanova str., 1.
Elmira P AdilgereevaFederal State Budgetary Institution «Research Centre for Medical Genetics» of the Russian Academy of Medical Sciences, Russia, 115478, Moscow, Moskvorechie, 1.
Evgeny D NekrasovMoscow Institute of Physics and Technology (State University), Russia, 141700, Moscow Region, Dolgoprudny, Institutskiy per., 9.
Alexander V LavrovFederal State Budgetary Institution «Research Centre for Medical Genetics» of the Russian Academy of Medical Sciences, Russia, 115478, Moscow, Moskvorechie, 1; State Budgetary Educational Institution of Higher Professional Education "Russian National Research Medical University named after N.I. Pirogov" of Ministry of Health of the Russian Federation, Russia, 117997, Moscow, Ostrovityanova str., 1.
Research Centre for Medical Genetics · RUMinistry of Health of the Russian Federation · RUMoscow Institute of Physics and Technology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chromosome arrangement in the interphase nucleus is not accidental. Strong evidences support that nuclear localization is an important mechanism of epigenetic regulation of gene expression. The purpose of this research was to identify differences in the localization of centromeres of chromosomes 6, 12, 18 and X in human mesenchymal stem cells depending on differentiation and cultivating time. We analyzed centromere positions in more than 4000 nuclei in 19 mesenchymal stem cell cultures before and after prolonged cultivation and after differentiation into osteogenic and adipogenic directions. We found a centromere reposition of HSAX at late passages and after differentiation in osteogenic direction as well as of HSA12 and HSA18 after adipogenic differentiation. The observed changes of the nuclear structure are new nuclear characteristics of the studied cells which may reflect regulatory changes of gene expression during the studied processes.

Indexed as

Cell DifferentiationCell NucleusCentromereChromosomes, Human, 6-12 and XChromosomes, Human, Pair 18Epigenesis, GeneticFemaleHumansIn Situ Hybridization, FluorescenceMaleMesenchymal Stem CellsPrimary Cell Culture

Identifiers

PMID25775427
PMCPMC4361746
OpenAlexW2059332752

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.