ArticlePloS one2015
Biotransformation of the mycotoxin deoxynivalenol in fusarium resistant and susceptible near isogenic wheat lines.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.
- Priority actions for Fusarium head blight resistance in durum wheat: Insights from the wheat initiative.The plant genome · 2025Pooled it
- Fusarium infection in malting barley drives trichothecene transfer and transformation during brewing process, impacting beer safety and composition.Mycotoxin research · 2026Article
- Influence of Light Spectrum on Bread Wheat Head Colonization byPlants (Basel, Switzerland) · 2025Article
- Temporal Wheat Proteome Remodeling by Deoxynivalenol Reveals Novel Detoxification Signatures and Strategies Across Cultivars.Molecular & cellular proteomics : MCP · 2025Article
- UDP-glycosyltransferases alleviate the toxic effects of deoxynivalenol on the growth performance and gut damage of Kunming mice.Scientific reports · 2025Article
- Effect of Fungicide Treatment on Multi-Mycotoxin Occurrence in French Wheat during a 4-Year Period.Toxins · 2023Article
- MultipleJournal of fungi (Basel, Switzerland) · 2023Article
- Untargeted Metabolomics Reveals a Multi-Faceted Resistance Response to Fusarium Head Blight Mediated by theCells · 2023Article
- Biocontrol Effect ofPlants (Basel, Switzerland) · 2023Article
- Identification of a UDP-glucosyltransferase conferring deoxynivalenol resistance in Aegilops tauschii and wheat.Plant biotechnology journal · 2023Article
- Reviews of fungi and mycotoxins in Chinese dark tea.Frontiers in microbiology · 2023Review
- Exploration of Mycotoxin Accumulation and Transcriptomes of Different Wheat Cultivars duringToxins · 2022Article
- Genetic architecture of fusarium head blight disease resistance and associated traits in Nordic spring wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Article
- Article
- Review
- Updated Review of the Toxicity of SelectedToxins · 2021Review
- Mycotoxins Biocontrol Methods for Healthier Crops and Stored Products.Journal of fungi (Basel, Switzerland) · 2021Review
- Transcriptome Alterations of anFrontiers in plant science · 2021Article
- Presence of the Weakly PathogenicFrontiers in plant science · 2021Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, a total of nine different biotransformation products of the Fusarium mycotoxin deoxynivalenol (DON) formed in wheat during detoxification of the toxin are characterized by liquid chromatography-high resolution mass spectrometry (LC-HRMS). The detected metabolites suggest that DON is conjugated to endogenous metabolites via two major metabolism routes, namely 1) glucosylation (DON-3-glucoside, DON-di-hexoside, 15-acetyl-DON-3-glucoside, DON-malonylglucoside) and 2) glutathione conjugation (DON-S-glutathione, "DON-2H"-S-glutathione, DON-S-cysteinyl-glycine and DON-S-cysteine). Furthermore, conjugation of DON to a putative sugar alcohol (hexitol) was found. A molar mass balance for the cultivar 'Remus' treated with 1 mg DON revealed that under the test conditions approximately 15% of the added DON were transformed into DON-3-glucoside and another 19% were transformed to the remaining eight biotransformation products or irreversibly bound to the plant matrix. Additionally, metabolite abundance was monitored as a function of time for each DON derivative and was established for six DON treated wheat lines (1 mg/ear) differing in resistance quantitative trait loci (QTL) Fhb1 and/or Qfhs.ifa-5A. All cultivars carrying QTL Fhb1 showed similar metabolism kinetics: Formation of DON-Glc was faster, while DON-GSH production was less efficient compared to cultivars which lacked the resistance QTL Fhb1. Moreover, all wheat lines harboring Fhb1 showed significantly elevated D3G/DON abundance ratios.
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Registered trials
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