Evidence map›Paper›PMID 25775358›Full record

ArticlePain2015

Female migraineurs show lack of insular thinning with age.

Nasim Maleki, Gabi Barmettler, Eric A Moulton, Steven Scrivani, Rosanna Veggeberg, Egilius L H Spierings, Rami Burstein, Lino Becerra, David Borsook

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pain, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  20. Migraine: What Imaging Reveals.Current neurology and neuroscience reports · 2016
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Nasim MalekiDepartment of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA Center for Pain and the Brain and PAIN Group, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Boston, MA, USA Department of Psychiatry, PAIN Group, Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA, USA Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Gabi Barmettler
Eric A Moulton
Steven Scrivani
Rosanna Veggeberg
Egilius L H Spierings
Rami Burstein
Lino Becerra
David Borsook

Funding

Brain Markers of Low and High Frequency Episodic MigraineR01NS073997 · NINDS · MCLEAN HOSPITAL · PI BORSOOK, DAVID · 2011 to 2015
$2.0M
Imaging Pain and Analgesia: Mentoring in Basic and Applied ResearchK24NS064050 · NINDS · MCLEAN HOSPITAL · PI BORSOOK, DAVID · 2008 to 2017
$1.7M
NINDS NIH HHS K24 NS064050NINDS NIH HHS K24-NS064050NINDS NIH HHS R01 NS073997NINDS NIH HHS R01-NS073997
6 · The paper itself

Abstract

Gray matter loss in cortical regions is a normal ageing process for the healthy brain. There have been few studies on the process of ageing of the brain in chronic neurological disorders. In this study, we evaluated changes in the cortical thickness by age in 92 female subjects (46 patients with migraine and 46 healthy controls) using high-field magnetic resonance imaging. The results indicate that in contrast to healthy subjects, migraineurs show a lack of thinning in the insula by age. The functional significance of the lack of thinning is unknown, but it may contribute to the overall cortical hyperexcitability of the migraine brain because the region is tightly involved in a number of major brain networks involved in interoception, salience, nociception, and autonomic function, including the default mode network.

Indexed as

AdultAgedAgingCerebral CortexCohort StudiesFemaleHumansMagnetic Resonance ImagingMiddle AgedMigraine DisordersNerve NetOrgan SizeYoung Adult

Identifiers

PMID25775358
PMCPMC4474740

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.