ArticlePLoS genetics2015
Hyperdiverse gene cluster in snail host conveys resistance to human schistosome parasites.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 88 citations in OpenAlex.
- Genomic basis of schistosome resistance in a molluscan vector of human schistosomiasis.iScience · 2025Article
- Unveiling the hemolymphatic miRNome composition of the schistosomiasis vector snailCurrent research in parasitology & vector-borne diseases · 2025Article
- Susceptibility of BS90 Biomphalaria glabrata snails to infection by SmLE Schistosoma mansoni segregates as a dominant allele in a cluster of polymorphic genes for single-pass transmembrane proteins.PLoS neglected tropical diseases · 2024Article
- Article
- Assessing the microbiota of the snail intermediate host of trematodes, Galba truncatula.Parasites & vectors · 2024Article
- The genome and transcriptome of the snailbioRxiv : the preprint server for biology · 2023Article
- A genome sequence for Biomphalaria pfeifferi, the major vector snail for the human-infecting parasite Schistosoma mansoni.PLoS neglected tropical diseases · 2023Article
- Complex patterns shape immune genes diversity during invasion of common raccoon in Europe - Selection in action despite genetic drift.Evolutionary applications · 2023Article
- Modeling the efficacy of CRISPR gene drive for snail immunity on schistosomiasis control.PLoS neglected tropical diseases · 2022Article
- Compatibility between snails and schistosomes: insights from new genetic resources, comparative genomics, and genetic mapping.Communications biology · 2022Article
- Genomic analysis of a parasite invasion: Colonization of the Americas by the blood fluke Schistosoma mansoni.Molecular ecology · 2022Article
- Nuclear genome of Bulinus truncatus, an intermediate host of the carcinogenic human blood fluke Schistosoma haematobium.Nature communications · 2022Article
- Article
- Experimental Infection of theMicroorganisms · 2021Article
- New Insights Into Biomphalysin Gene Family Diversification in the Vector SnailFrontiers in immunology · 2021Article
- Article
- An Overview of Transcriptional Responses of Schistosome-Susceptible (M line) or -Resistant (BS-90)Frontiers in immunology · 2021Article
- Article
- Heat shock increases hydrogen peroxide release from circulating hemocytes of the snail Biomphalaria glabrata.Fish & shellfish immunology · 2020Article
- Clusters of polymorphic transmembrane genes control resistance to schistosomes in snail vectors.eLife · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Schistosomiasis, a neglected global pandemic, may be curtailed by blocking transmission of the parasite via its intermediate hosts, aquatic snails. Elucidating the genetic basis of snail-schistosome interaction is a key to this strategy. Here we map a natural parasite-resistance polymorphism from a Caribbean population of the snail Biomphalaria glabrata. In independent experimental evolution lines, RAD genotyping shows that the same genomic region responds to selection for resistance to the parasite Schistosoma mansoni. A dominant allele in this region conveys an 8-fold decrease in the odds of infection. Fine-mapping and RNA-Seq characterization reveal a <1Mb region, the Guadeloupe Resistance Complex (GRC), with 15 coding genes. Seven genes are single-pass transmembrane proteins with putative immunological roles, most of which show strikingly high nonsynonymous divergence (5-10%) among alleles. High linkage disequilibrium among three intermediate-frequency (>25%) haplotypes across the GRC, a significantly non-neutral pattern, suggests that balancing selection maintains diversity at the GRC. Thus, the GRC resembles immune gene complexes seen in other taxa and is likely involved in parasite recognition. The GRC is a potential target for controlling transmission of schistosomiasis, including via genetic manipulation of snails.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.