ArticleBMC psychiatry2015
The two-year course of late-life depression; results from the Netherlands study of depression in older persons.
Article in BMC psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence and Associated Factors of Chronic Depression Among Older Adults: A Systematic Review, Meta-Analysis, and Meta-Regression.International journal of geriatric psychiatry · 2025Pooled it
- Cortical inhibition, facilitation and plasticity in late-life depression: effects of venlafaxine pharmacotherapy.Journal of psychiatry & neuroscience : JPN · 2021Trial
- Trial
- Efficacy, tolerability, and cognitive effects of deep transcranial magnetic stimulation for late-life depression: a prospective randomized controlled trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Trial
- Trial
- Cognitive control training as an add-on treatment for late-life depression: A multicenter randomized controlled trial.Internet interventions · 2026Article
- Cognitive impairment and depressive symptoms to predict renal outcome and mortality in older adult patients.PloS one · 2026Article
- Persistence and Determinants of Late-Life Depression: Results of the Nationally Representative Longitudinal German Aging Survey 2008 to 2023.International journal of geriatric psychiatry · 2025Article
- Association of Subjective Social Support With Antidepressant Treatment Response Among Older Depressed Adults in the Neurobiology of Late-Life Depression Study.The American journal of geriatric psychiatry. Open science, education, and practice · 2025Article
- One-Year Changes in Depressive Symptoms and Cognitive Function Among Brazilian Older Adults Attending Primary Care.Healthcare (Basel, Switzerland) · 2025Article
- Building Consensus on the Relevant Criteria to Screen for Depressive Symptoms Among Near-Centenarians and Centenarians: Modified e-Delphi Study.JMIR aging · 2025Article
- Trajectories of generalized anxiety disorder, major depression and change in quality of life in adults aged 50 + : findings from a longitudinal analysis using representative, population-based data from Ireland.Social psychiatry and psychiatric epidemiology · 2023Observational
- The heterogeneity of late-life depression and its pathobiology: a brain network dysfunction disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2023Review
- Age as a moderating factor of treatment resistance in depression.European psychiatry : the journal of the Association of European Psychiatrists · 2023Article
- Social support score in patients with malignant diseases-with sociodemographic and medical characteristics.Frontiers in psychology · 2023Article
- Validation of the Longitudinal Interval Follow-Up Evaluation for the Long-Term Measurement of Mood Symptoms in Bipolar Disorder.Brain sciences · 2022Article
- Factors associated with onset-age in major affective disorders.Acta psychiatrica Scandinavica · 2022Article
- The dose-effect relationships of cigarette and alcohol consumption with depressive symptoms: a multiple-center, cross-sectional study in 5965 Chinese middle-aged and elderly men.BMC psychiatry · 2022Article
- The enigma of vascular depression in old age: a critical update.Journal of neural transmission (Vienna, Austria : 1996) · 2022Review
- Determinants and consequences of polypharmacy in patients with a depressive disorder in later life.Acta psychiatrica Scandinavica · 2022Observational
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe aimed to examine the course of depression during 2-year follow-up in a group clinically depressed older persons. Subsequently, we studied which socio-demographic and clinical characteristics predict a depression diagnoses at 2-year follow-up.
methodsData were used from the Netherlands Study of Depression in Older persons (NESDO; N = 510). Diagnoses of depression DSM-IV-TR criteria were available from 285 patients at baseline and at 2-year follow-up. Severity of the depressive symptoms, as assessed with the Inventory of Depressive Symptoms (IDS), was obtained from 6-monthly postal questionnaires. Information about socio-demographic and clinical variables was obtained from the baseline measurement.
resultFrom the 285 older persons who were clinically depressed at baseline almost half (48.4%) also suffered from a depressive disorder two years later. Patients with more severe depressive symptoms, comorbid dysthymia, younger age of onset and more chronic diseases were more likely to be depressed at 2-year follow-up. 61% of the persons that were depressed at baseline had a chronic course of depressive symptoms during these two years.
conclusionsLate-life depression often has a chronic course, even when treated conform current guidelines for older persons. Our results suggest that physical comorbidity may be candidate for adjusted and intensified treatment strategies of older depressed patients with chronic and complex pathology.
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