ArticlePloS one2015
Transcriptome analysis of the white body of the squid Euprymna tasmanica with emphasis on immune and hematopoietic gene discovery.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Multiple evolutionary routes to immune diversification across animals.International immunology · 2026Review
- A single-cell atlas of the bobtail squid visual and nervous system highlights molecular principles of convergent evolution.Nature ecology & evolution · 2025Article
- Transcriptomic responses in the nervous system and correlated behavioural changes of a cephalopod exposed to ocean acidification.BMC genomics · 2024Article
- Insights into Common Octopus (Marine drugs · 2023Article
- A lasting symbiosis: how the Hawaiian bobtail squid finds and keeps its bioluminescent bacterial partner.Nature reviews. Microbiology · 2021Review
- Persistent symbiont colonization leads to a maturation of hemocyte response in the Euprymna scolopes/Vibrio fischeri symbiosis.MicrobiologyOpen · 2019Article
- Global impact of diet and temperature over aquaculture of Octopus vulgaris paralarvae from a transcriptomic approach.Scientific reports · 2019Article
- Article
- New bobtail squid (Sepiolidae: Sepiolinae) from the Ryukyu islands revealed by molecular and morphological analysis.Communications biology · 2019Article
- Transcriptomic Analysis Reveals Insights on Male Infertility inFrontiers in physiology · 2018Article
- Comparative immunogenomics of molluscs.Developmental and comparative immunology · 2017Review
- The Gastric Ganglion ofFrontiers in physiology · 2017Article
- Haematopoiesis in molluscs: A review of haemocyte development and function in gastropods, cephalopods and bivalves.Developmental and comparative immunology · 2016Review
- The Role of Hemocytes in the Hawaiian Bobtail Squid,Frontiers in microbiology · 2016Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the mutualistic relationship between the squid Euprymna tasmanica and the bioluminescent bacterium Vibrio fischeri, several host factors, including immune-related proteins, are known to interact and respond specifically and exclusively to the presence of the symbiont. In squid and octopus, the white body is considered to be an immune organ mainly due to the fact that blood cells, or hemocytes, are known to be present in high numbers and in different developmental stages. Hence, the white body has been described as the site of hematopoiesis in cephalopods. However, to our knowledge, there are no studies showing any molecular evidence of such functions. In this study, we performed a transcriptomic analysis of white body tissue of the Southern dumpling squid, E. tasmanica. Our primary goal was to gain insights into the functions of this tissue and to test for the presence of gene transcripts associated with hematopoietic and immune processes. Several hematopoiesis genes including CPSF1, GATA 2, TFIID, and FGFR2 were found to be expressed in the white body. In addition, transcripts associated with immune-related signal transduction pathways, such as the toll-like receptor/NF-κβ, and MAPK pathways were also found, as well as other immune genes previously identified in E. tasmanica's sister species, E. scolopes. This study is the first to analyze an immune organ within cephalopods, and to provide gene expression data supporting the white body as a hematopoietic tissue.
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