Evidence map›Paper›PMID 25774978›Full record

ArticlePloS one2015

Comb-push ultrasound shear elastography of breast masses: initial results show promise.

Max Denis, Mohammad Mehrmohammadi, Pengfei Song, Duane D Meixner, Robert T Fazzio, Sandhya Pruthi, Dana H Whaley, Shigao Chen, Mostafa Fatemi, Azra Alizad

Abstract read
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Article
  3. Correlation-based full-waveform shear wave elastography.Physics in medicine and biology · 2023
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Evaluation of Reconstruction Parameters for 2-D Comb-Push Ultrasound Shear Wave Elastography.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2019
    Article
  13. Article
  14. Dual-Phase Transmit Focusing for Multiangle Compound Shear-Wave Elasticity Imaging.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2017
    Article
  15. Article
  16. Automated Compression Device for Viscoelasticity Imaging.IEEE transactions on bio-medical engineering · 2017
    Article
  17. Mechanics of ultrasound elastography.Proceedings. Mathematical, physical, and engineering sciences · 2017
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Max DenisDepartment of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.
Mohammad MehrmohammadiDepartment of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.
Pengfei SongDepartment of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.
Duane D MeixnerDepartment of Radiology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.
Robert T FazzioDepartment of Radiology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.
Sandhya PruthiDepartment of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.
Dana H WhaleyDepartment of Radiology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.
Shigao ChenDepartment of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.
Mostafa FatemiDepartment of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.
Azra AlizadDepartment of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America; Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.

Funding

Classification of breast masses based on visco-elastic propertiesR01CA168575 · NCI · MAYO CLINIC ROCHESTER · PI FATEMI, MOSTAFA, INSANA, MICHAEL F · 2013 to 2018
$2.5M
Combined Acoustic Imaging and Viscoelastic Parameters Estimation in Breast CancerR01CA148994 · NCI · MAYO CLINIC ROCHESTER · PI ALIZAD, AZRA · 2011 to 2015
$2.4M
NCI NIH HHS R01 CA148994NCI NIH HHS R01CA148994NCI NIH HHS R01CA148994-04S1NCI NIH HHS R01 CA168575NCI NIH HHS R01CA168575
6 · The paper itself

Abstract

PURPOSE OR

objectiveTo evaluate the performance of Comb-push Ultrasound Shear Elastography (CUSE) for classification of breast masses. MATERIALS AND

methodsCUSE is an ultrasound-based quantitative two-dimensional shear wave elasticity imaging technique, which utilizes multiple laterally distributed acoustic radiation force (ARF) beams to simultaneously excite the tissue and induce shear waves. Female patients who were categorized as having suspicious breast masses underwent CUSE evaluations prior to biopsy. An elasticity estimate within the breast mass was obtained from the CUSE shear wave speed map. Elasticity estimates of various types of benign and malignant masses were compared with biopsy results.

resultsFifty-four female patients with suspicious breast masses from our ongoing study are presented. Our cohort included 31 malignant and 23 benign breast masses. Our results indicate that the mean shear wave speed was significantly higher in malignant masses (6 ± 1.58 m/s) in comparison to benign masses (3.65 ± 1.36 m/s). Therefore, the stiffness of the mass quantified by the Young's modulus is significantly higher in malignant masses. According to the receiver operating characteristic curve (ROC), the optimal cut-off value of 83 kPa yields 87.10% sensitivity, 82.61% specificity, and 0.88 for the area under the curve (AUC).

conclusionCUSE has the potential for clinical utility as a quantitative diagnostic imaging tool adjunct to B-mode ultrasound for differentiation of malignant and benign breast masses.

Indexed as

AdultAgedBreastBreast NeoplasmsDiagnosis, DifferentialElasticity Imaging TechniquesElastic ModulusFemaleHumansMiddle AgedROC CurveUltrasonography, Mammary

Identifiers

PMID25774978
PMCPMC4361045

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.