ArticlePLoS genetics2015
The nuclear receptor DAF-12 regulates nutrient metabolism and reproductive growth in nematodes.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 51 citations in OpenAlex.
- Conservation of Nuclear Receptor DAF-12 with Evidence for Ligand Diversification in Plant-Parasitic Nematodes.bioRxiv : the preprint server for biology · 2026Article
- A new set of combinatorial dimeric codes for nuclear hormone receptor-target gene specificity.Nucleic acids research · 2026Article
- CRISPR/Cas genome editing, functional genomics, and diagnostics for parasitic helminths.International journal for parasitology · 2025Review
- Nuclear receptors in health and disease: signaling pathways, biological functions and pharmaceutical interventions.Signal transduction and targeted therapy · 2025Review
- A standard workflow for community-driven manual curation ofPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Astacin metalloproteases in human-parasitic nematodes.Advances in parasitology · 2024Review
- A drug-like molecule engages nuclear hormone receptor DAF-12/FXR to regulate mitophagy and extend lifespan.Nature aging · 2023Article
- Changes in lipid metabolism driven by steroid signalling modulate proteostasis in C. elegans.EMBO reports · 2023Article
- Fatty acids derived from the probiotic Lacticaseibacillus rhamnosus HA-114 suppress age-dependent neurodegeneration.Communications biology · 2022Article
- Molecular Cloning and Characterization of aPathogens (Basel, Switzerland) · 2022Article
- Gene regulatory network inference in long-livediScience · 2022Article
- Characterization of the endogenous DAF-12 ligand and its use as an anthelmintic agent ineLife · 2021Article
- Endocrine pheromones couple fat rationing to dauer diapause through HNF4α nuclear receptors.Science China. Life sciences · 2021Article
- Article
- Identification of a nuclear receptor/coactivator developmental signaling pathway in the nematode parasiteProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Exposure to dexamethasone modifies transcriptomic responses of free-living stages of Strongyloides stercoralis.PloS one · 2021Article
- Rhabditophanes diutinus a parthenogenetic clade IV nematode with dauer larvae.PLoS pathogens · 2020Article
- The C. elegans miR-235 regulates the toxicity of graphene oxide via targeting the nuclear hormone receptor DAF-12 in the intestine.Scientific reports · 2020Article
- Article
- Recent advances in functional genomics for parasitic nematodes of mammals.The Journal of experimental biology · 2020Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Appropriate nutrient response is essential for growth and reproduction. Under favorable nutrient conditions, the C. elegans nuclear receptor DAF-12 is activated by dafachronic acids, hormones that commit larvae to reproductive growth. Here, we report that in addition to its well-studied role in controlling developmental gene expression, the DAF-12 endocrine system governs expression of a gene network that stimulates the aerobic catabolism of fatty acids. Thus, activation of the DAF-12 transcriptome coordinately mobilizes energy stores to permit reproductive growth. DAF-12 regulation of this metabolic gene network is conserved in the human parasite, Strongyloides stercoralis, and inhibition of specific steps in this network blocks reproductive growth in both of the nematodes. Our study provides a molecular understanding for metabolic adaptation of nematodes to their environment, and suggests a new therapeutic strategy for treating parasitic diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.