ArticlePloS one2015
The flavoproteins CryD and VvdA cooperate with the white collar protein WcoA in the control of photocarotenogenesis in Fusarium fujikuroi.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 38 citations in OpenAlex.
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- How fungi see the world: fungal photoreceptors and their role in the regulation of fungal biology.Microbiology and molecular biology reviews : MMBR · 2025Review
- Genome sequencing and comparative genomics reveal insights into pathogenicity and evolution of Fusarium zanthoxyli, the causal agent of stem canker in prickly ash.BMC genomics · 2024Article
- Genetic and Environmental Factors Influencing the Production of Select Fungal Colorants: Challenges and Opportunities in Industrial Applications.Journal of fungi (Basel, Switzerland) · 2023Review
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- Transcriptome sequencing and global analysis of blue light-responsive genes provide clues for high carotenoid yields in Blakeslea trispora.International microbiology : the official journal of the Spanish Society for Microbiology · 2022Article
- Relation between CarS expression and activation of carotenogenesis by stress inFrontiers in bioengineering and biotechnology · 2022Article
- TheNon-coding RNA · 2021Article
- Structure prediction and function characterization of WC-2 proteins in Blakeslea trispora.International microbiology : the official journal of the Spanish Society for Microbiology · 2021Article
- A light life together: photosensing in the plant microbiota.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2021Review
- A novel lncRNA as a positive regulator of carotenoid biosynthesis in Fusarium.Scientific reports · 2020Article
- Impact of the White Collar Photoreceptor WcoA on theFrontiers in microbiology · 2020Article
- Comparative transcriptomic analysis unveils interactions between the regulatory CarS protein and light response in Fusarium.BMC genomics · 2019Article
- The contribution of the White Collar complex to Cryptococcus neoformans virulence is independent of its light-sensing capabilities.Fungal genetics and biology : FG & B · 2018Article
- Carotenoid Biosynthesis in Fusarium.Journal of fungi (Basel, Switzerland) · 2017Review
- Seeing the world differently: variability in the photosensory mechanisms of two model fungi.Environmental microbiology · 2016Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Light stimulates carotenoid biosynthesis in the ascomycete fungus Fusarium fujikuroi through transcriptional activation of the structural genes of the pathway carRA, carB, and cart, but the molecular basis of this photoresponse is unknown. The F. fujikuroi genome contains genes for different predicted photoreceptors, including the WC protein WcoA, the DASH cryptochrome CryD and the Vivid-like flavoprotein VvdA. We formerly found that null mutants of wcoA, cryD or vvdA exhibit carotenoid photoinduction under continuous illumination. Here we show that the wild type exhibits a biphasic response in light induction kinetics experiments, with a rapid increase in carotenoid content in the first hours, a transient arrest and a subsequent slower increase. The mutants of the three photoreceptors show different kinetic responses: the wcoA mutants are defective in the rapid response, the cryD mutants are affected in the slower response, while the fast and slow responses were respectively enhanced and attenuated in the vvdA mutants. Transcriptional analyses of the car genes revealed a strong reduction of dark and light-induced transcript levels in the wcoA mutants, while minor or no reductions were found in the cryD mutants. Formerly, we found no change on carRA and carB photoinduction in vvdA mutants. Taken together, our data suggest a cooperative participation of WcoA and CryD in early and late stages of photoinduction of carotenoid biosynthesis in F. fujikuroi, and a possible modulation of WcoA activity by VvdA. An unexpected transcriptional induction by red light of vvdA, cryD and carRA genes suggest the participation of an additional red light-absorbing photoreceptor.
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