ArticlePloS one2015
Increased perfusion in normal appearing white matter in high inflammatory multiple sclerosis patients.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Non-invasive kinetic modelling approaches for quantitative analysis of brain PET studies.European journal of nuclear medicine and molecular imaging · 2023Pooled it
- Imaging vascular and hemodynamic features of the brain using dynamic susceptibility contrast and dynamic contrast enhanced MRI.NeuroImage · 2019Pooled it
- Rapid simultaneous estimation of relaxation rates using multi-echo, multi-contrast MRI.Magnetic resonance imaging · 2024Article
- Age-related decline in cerebral oxygen consumption in multiple sclerosis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- The impact of body position on neurofluid dynamics: present insights and advancements in imaging.Frontiers in aging neuroscience · 2024Review
- Pathophysiology of multiple sclerosis damage and repair: Linking cerebral hypoperfusion to the development of irreversible tissue loss in multiple sclerosis using magnetic resonance imaging.European journal of neurology · 2023Article
- Cerebrovascular reactivity in multiple sclerosis is restored with reduced inflammation during immunomodulation.Scientific reports · 2022Article
- Angiogenesis and Multiple Sclerosis Pathogenesis: A Glance at New Pharmaceutical Approaches.Journal of clinical medicine · 2022Review
- Role of hepatitis c virus in hepatocellular carcinoma and neurological disorders: an overview.Frontiers in oncology · 2022Review
- Characteristics of cerebral blood flow in an Eastern sample of multiple sclerosis patients: A potential quantitative imaging marker associated with disease severity.Frontiers in immunology · 2022Article
- Neurological and psychiatric effects of hepatitis C virus infection.World journal of gastroenterology · 2021Review
- Quantitative magnetic resonance imaging towards clinical application in multiple sclerosis.Brain : a journal of neurology · 2021Review
- Revealing vascular abnormalities and measuring small vessel density in multiple sclerosis lesions using USPIO.NeuroImage. Clinical · 2021Article
- Blood Oxygenation Level-Dependent Response to Multiple Grip Forces in Multiple Sclerosis: Going Beyond the Main Effect of Movement in Brodmann Area 4a and 4p.Frontiers in cellular neuroscience · 2021Article
- An Overview of Venous Abnormalities Related to the Development of Lesions in Multiple Sclerosis.Frontiers in neurology · 2021Review
- From Neurodevelopmental to Neurodegenerative Disorders: The Vascular Continuum.Frontiers in aging neuroscience · 2021Review
- Neuroimaging Findings in Chronic Hepatitis C Virus Infection: Correlation with Neurocognitive and Neuropsychiatric Manifestations.International journal of molecular sciences · 2020Review
- Relationship between MRI perfusion and clinical severity in multiple sclerosis.Neural regeneration research · 2020Review
- Standardization of T1w/T2w Ratio Improves Detection of Tissue Damage in Multiple Sclerosis.Frontiers in neurology · 2019Article
- The features of cerebral permeability and perfusion detected by dynamic contrast-enhanced magnetic resonance imaging with Patlak model in relapsing-remitting multiple sclerosis.Therapeutics and clinical risk management · 2019Article
Corrections and comments
- Erratum issuedCorrection: Increased Perfusion in Normal Appearing White Matter in High Inflammatory Multiple Sclerosis Patients.2015 · Stürner, Klarissa [added]
Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAlthough cerebral perfusion alterations have long been acknowledged in multiple sclerosis (MS), the relationship between measurable perfusion changes and the status of highly active MS has not been examined. We hypothesized that alteration of perfusion can be detected in normal appearing white matter and is increased in high inflammatory patients. MATERIALS AND
methodsThirty-three patients with relapsing-remitting MS underwent four monthly 3T MRI scans including dynamic susceptibility contrast perfusion-weighted MRI. Cerebral blood flow (CBF) and cerebral blood volume (CBV) were measured in normal appearing white matter. Patients were stratified in a high- and low-inflammatory group according to the number of new contrast enhancing lesions.
resultsThirteen patients were classified as high-inflammatory. Compared to low-inflammatory patients, the high-inflammatory group demonstrated significantly higher CBV (p = 0.001) and CBF (p = 0.014) values. A mixed model analysis to assess independent variables associated with CBV and CBF revealed that white matter lesion load and atrophy measurements had no significant influence on CBF and CBV.
conclusionThis work provides evidence that high inflammatory lesion load is associated with increased CBV and CBF, underlining the role of global modified microcirculation prior to leakage of the blood-brain barrier in the pathophysiology of MS. Perfusion changes might therefore be sensitive to active inflammation apart from lesion development without local blood-brain barrier breakdown, and could be utilized to further assess the metabolic aspect of current inflammation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.