Evidence map›Paper›PMID 25774328›Full record

ArticleTranslational vision science & technology2014

One-Year Feasibility Study of Replenish MicroPump for Intravitreal Drug Delivery: A Pilot Study.

Juan-Carlos Gutiérrez-Hernández, Sean Caffey, Walid Abdallah, Phillip Calvillo, Roberto González, Jason Shih, Jeff Brennan, Jenna Zimmerman, Juan-Carlos Martínez-Camarillo, Anthony R Rodriguez and 4 more

Abstract read
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In one paragraph

Article in Translational vision science & technology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 30 citations in OpenAlex.

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  3. Intraocular Pressure-Lowering Efficacy of a Sustained-Release Bimatoprost Implant in Dog Eyes Pretreated with Selective Laser Trabeculoplasty.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2022
    Article
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  7. Review
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  9. Article
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  11. Article
  12. New Therapeutic Approaches in Diabetic Retinopathy.The review of diabetic studies : RDS
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Juan-Carlos Gutiérrez-HernándezDoheny Eye Institute, Los Angeles, CA ; Centro de Retina Médica y Quirúrgica, SC, Zapopan, Jalisco, Mexico.
Sean CaffeyReplenish Inc., Pasadena, CA.
Walid AbdallahReplenish Inc., Pasadena, CA ; Department of Ophthalmology, Zagazig University, Faculty of Medicine, Zagazig, Egypt ; Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Phillip CalvilloReplenish Inc., Pasadena, CA.
Roberto GonzálezReplenish Inc., Pasadena, CA.
Jason ShihReplenish Inc., Pasadena, CA.
Jeff BrennanReplenish Inc., Pasadena, CA.
Jenna ZimmermanReplenish Inc., Pasadena, CA.
Juan-Carlos Martínez-CamarilloDoheny Eye Institute, Los Angeles, CA ; Centro de Retina Médica y Quirúrgica, SC, Zapopan, Jalisco, Mexico.
Anthony R RodriguezDoheny Eye Institute, Los Angeles, CA.
Rohit VarmaDepartment of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Arturo SantosCentro de Retina Médica y Quirurgica, SC and Tecnológico de Monterrey, Campus Guadalajara, Mexico.
Gisela SánchezCentro de Retina Médica y Quirurgica, SC and Tecnológico de Monterrey, Campus Guadalajara, Mexico.
Mark HumayunReplenish Inc., Pasadena, CA ; Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Centro de Retina Médica y Quirúrgica · MXDoheny Eye Institute · USTecnológico de Monterrey · MXUniversity of Southern California · US

Funding

VISION RESEARCHP30EY003040 · NEI · DOHENY EYE INSTITUTE · PI SUN, DEMING · 1985 to 2013
$7.0M
NEI NIH HHS P30 EY003040
6 · The paper itself

Abstract

purposeTo determine the feasibility of the surgical procedure and to collect some safety data regarding the bioelectronics of a novel micro drug pump for intravitreal drug delivery in a Beagle dog model for up to 1 year.

methodsThirteen Beagle dogs were assigned to two groups. The experimental group (

resultsEyes were scored according to a modified McDonald-Shadduck system and ophthalmic imaging. Neither the implanted eyes nor the control eyes showed clinically significant pathological changes beyond the expected surgical changes. The operated eyes showed neither significant inflammatory reaction nor tissue ingrowth through the sclerotomy site compared with the fellow eyes.

conclusionThis study shows that the Replenish Posterior MicroPump could be successfully implanted with good safety profile in this animal model. TRANSLATIONAL RELEVANCE: The results of this study in a Beagle dog model are supportive of the biocompatibility of Replenish MicroPump and pave the way to the use of these devices for ocular automated drug delivery after further testing in larger animal models.

Indexed as

biocompatibilityintravitreal drug deliverymicropump

Identifiers

PMID25774328
PMCPMC4356354
OpenAlexW1982480819

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.