Evidence map›Paper›PMID 25774288›Full record

ArticleClinical and translational allergy2015

Food allergy in the Netherlands: differences in clinical severity, causative foods, sensitization and DBPCFC between community and outpatients.

Thuy-My Le, Els van Hoffen, Ischa Kummeling, James Potts, Barbara K Ballmer-Weber, Carla Afm Bruijnzeel-Koomen, Ans Fm Lebens, Jonas Lidholm, Titia M Lindner, Alan Mackie and 6 more

Open access · goldAbstract read
In one paragraph

Article in Clinical and translational allergy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Diagnostic accuracy of Ara h 2 for detecting peanut allergy in children.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021
    Article
  6. Review
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 9 institutions in 6 countries.

Thuy-My LeDepartment of Dermatology/Allergology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands.
Els van HoffenDepartment of Dermatology/Allergology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands ; Current affiliation: NIZO food research, Ede, The Netherlands.
Ischa KummelingDepartment of Dermatology/Allergology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands ; Department of Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College London, London, UK.
James PottsDepartment of Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College London, London, UK.
Barbara K Ballmer-WeberAllergy Unit, Department of Dermatology, University Hospital Zürich, Zürich, Switzerland.
Carla Afm Bruijnzeel-KoomenDepartment of Dermatology/Allergology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands.
Ans Fm LebensDepartment of Dermatology/Allergology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands.
Jonas LidholmThermo Fisher Scientific, Uppsala, Sweden.
Titia M LindnerDepartment of Dermatology/Allergology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands.
Alan MackieInstitute of Food Research, Norwich Research Park, Colney, Norwich, NR4 7UA UK.
En Clare MillsInstitute of Inflammation and Repair, Manchester Academic Health Sciences Centre, Manchester Institute of Biotechnology, The University of Manchester, Manchester, UK.
Ronald van ReeDepartment of Experimental Immunology and Department of Otorhinolaryngology, Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands.
Stefan ViethsDivision of Allergology, Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines, Langen, Germany.
Montserrat Fernández-RivasAllergy Department, Hospital Clinico San Carlos, IdISSC, Madrid, Spain.
Peter G BurneyDepartment of Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College London, London, UK.
André C KnulstDepartment of Dermatology/Allergology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands.
University Medical Center Utrecht · NLImperial College London · GBAcademic Medical Center · NLHospital Clínico San Carlos · ESManchester Academic Health Science Centre · GBNorwich Research Park · GBPaul Ehrlich Institut · DEThermo Fisher Scientific (Sweden) · SEUniversity Hospital of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt is unknown whether food allergy (FA) in an unselected population is comparable to those from an outpatient clinic population.

objectiveTo discover if FA in a random sample from the Dutch community is comparable to that of outpatients.

methodsThis study was part of the Europrevall-project. A random sample of 6600 adults received a questionnaire. Those with symptoms to one of 24 defined priority foods were tested for sIgE. Participants with a positive case history and elevated sIgE were evaluated by double-blind placebo-controlled food challenge (DBPCFC). Outpatients with a suspicion of FA were evaluated by questionnaire, sIgE and DBPCFC.

resultsIn the community, severe symptoms were reported less often than in outpatients (39.3% vs. 54.3%). Participants in the community were less commonly sensitized to any of the foods. When selecting only those with a probable FA (i.e. symptoms of priority food and elevation of sIgE to the respective food), no major differences were observed with respect to severity, causative foods, sensitization and DBPCFC between the groups.

conclusionIn the Netherlands, there are large differences in self-reported FA between community and outpatients. However, Dutch community and outpatients with a probable FA do not differ with respect to severity, causative foods, sensitization and DBPCFC-outcome.

Indexed as

AdultsCommunityDBPCFCFood allergysIgE

Identifiers

PMID25774288
PMCPMC4359480
OpenAlexW2099132384

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.