ArticleJundishapur journal of microbiology2014
Detection of Metallo-Beta Lactamases Among Carbapenem-Resistant Pseudomonas aeruginosa.
Article in Jundishapur journal of microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Pooled it
- Virulence Traits and Drug Resistance of STEC Isolated from Layer Poultry andMicroorganisms · 2026Article
- Serogroups, antibiotic resistance profiles and virulence factors of non-O157 Shiga-toxin producing Escherichia coli from ovine and caprine.Scientific reports · 2026Article
- Prevalence of exotoxin and type III secretion system genes in multidrug-resistant Pseudomonas aeruginosa isolates from patients with burn injuries in Southern Iran.BMC infectious diseases · 2025Article
- Article
- Detection of Virulence Factors and Antibiotic Resistance amongBioMed research international · 2023Article
- Phenotypic and genotypic detection of resistance mechanisms in carbapenem-resistant gram-negative bacteria isolated from Egyptian ICU patients with first emergence of NDM-1 producingIranian journal of microbiology · 2022Article
- Analysis of carbapenemases genes of carbapenem-resistantIranian journal of microbiology · 2022Article
- The Antimicrobial Resistance Characteristics of Imipenem-Non-Susceptible, Imipenemase-6-ProducingAntibiotics (Basel, Switzerland) · 2021Article
- Distribution of Class 1-3 Integrons in Carbapenem-ResistantEthiopian journal of health sciences · 2021Article
- Emerge of NDM-1-Producing Multidrug-ResistantIranian journal of public health · 2020Article
- Colistin-resistantGut pathogens · 2020Article
- AntipseudomonalInternational journal of microbiology · 2020Review
- The threat of carbapenem-resistant gram-negative bacteria in a Middle East region.Infection and drug resistance · 2018Review
- Prevalence ofIranian journal of pathology · 2018Article
- Extensive colonization with carbapenemase-producing microorganisms in Romanian burn patients: infectious consequences from the Colectiv fire disaster.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Article
- Article
- The frequency of class1 and 2 integrons in Pseudomonas aeruginosa strains isolated from burn patients in a burn center of Ahvaz, Iran.PloS one · 2017Article
- Evaluation of Metallo-β-Lactamase-Production and Carriage ofArchives of trauma research · 2016Article
- Emergence of colistin resistant Pseudomonas aeruginosa at Tabriz hospitals, Iran.Iranian journal of microbiology · 2016Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCarbapenems are important drugs used for the treatment of Pseudomonas aeruginosa infections, however metallo-β-lactamases (MBL) are able to efficiently hydrolyze these classes of drugs. Immediate detection of the MBL-producing P. aeruginosa is necessary in order to accurately treat infections caused by this organism.
objectivesTo determine the prevalence of MBL producing P. aeruginosa in burn and non-burn patients by two phenotypic tests and polymerase chain reaction (PCR) and to compare phenotypic tests with PCR. MATERIALS AND
methodsA total of 223 non-duplicate strains of P. aeruginosa were collected from three teaching hospitals of Ahvaz, Iran. Antimicrobial susceptibility and minimum inhibitory concentrations (MICs) of carbapenems (imipenem, meropenem, doripenem and ertapenem) were determined by the Kirby-Bauer and E-test methods. Combined disk (CD) test, MBL E-test and PCR were performed for carbapenem-resistant P. aeruginosa isolates.
resultsAmongst all the P. aeruginosa isolates, 58.7% were resistant to imipenem while 31.8%, 13.5% and 74.4% were resistant to meropenem, doripenem and ertapenem, respectively. Amongst all the P. aeruginosa isolates, 44.4% were multidrug resistant and 13.45% were resistant to all of the carbapenems. The CD test with doripenem disk / 750 μg ethylene diamine tetra acetic acid (EDTA) had the highest efficiency compared to the other phenotypic tests. bla IMP and bla VIM genes were detected in 11.7% and 0.4% of isolates, respectively. bla SPM and bla NDM genes were not observed.
conclusionsEpidemiological and regional evaluation of MBL-producing P. aeruginosa through simple and inexpensive methods should be considered for effective treatment of carbapenem-resistant P. aeruginosa infections.
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