Evidence map›Paper›PMID 25774239›Full record

ArticleJournal of ophthalmic inflammation and infection2015

Unilateral acute maculopathy associated with adult onset hand, foot and mouth disease: case report and review of literature.

Rupesh Agrawal, Kanchan Bhan, Kam Balaggan, Richard Wj Lee, Carlos E Pavesio, Peter Kf Addison

Open access · goldAbstract read
In one paragraph

Article in Journal of ophthalmic inflammation and infection, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Hand, Foot, and Mouth Disease: A Narrative Review.Recent advances in inflammation & allergy drug discovery · 2022
    Review
  5. ["Hand, foot, eye?"]Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2020
    Article
  6. Article
  7. Article
  8. A Rare Case of Unilateral Acute Idiopathic Maculopathy in Young Male.Journal of clinical and diagnostic research : JCDR · 2017
    Article
  9. Article
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Rupesh AgrawalMoorfields Eye Hospital, NHS Foundation Trust, 162 City Road, London, EC1V 2PD UK ; Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, 162 City Road, London, EC1V 2PD UK ; National Healthcare Group Eye Institute, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore, 308433 Singapore.
Kanchan BhanMoorfields Eye Hospital, NHS Foundation Trust, 162 City Road, London, EC1V 2PD UK.
Kam BalagganMoorfields Eye Hospital, NHS Foundation Trust, 162 City Road, London, EC1V 2PD UK.
Richard Wj LeeMoorfields Eye Hospital, NHS Foundation Trust, 162 City Road, London, EC1V 2PD UK ; Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, 162 City Road, London, EC1V 2PD UK ; University Hospitals Bristol NHS Foundation Trust, Upper Maudlin Street, Bristol, BS2 8HW UK.
Carlos E PavesioMoorfields Eye Hospital, NHS Foundation Trust, 162 City Road, London, EC1V 2PD UK ; Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, 162 City Road, London, EC1V 2PD UK.
Peter Kf AddisonMoorfields Eye Hospital, NHS Foundation Trust, 162 City Road, London, EC1V 2PD UK.
Moorfields Eye Hospital NHS Foundation Trust · GBMoorfields Eye Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute maculopathy is a rare condition of unknown aetiology and Coxsackie virus is known to be associated with this macular chorioretinitis.

findingsWe report a case of acute unilateral maculopathy in a 35-year-old woman with concurrent hand foot and mouth disease. Furthermore, we display multimodal imaging (colour fundus photographs, autofluorescence, spectral domain ocular coherence tomography, fluorescein angiography and indocyanine green angiography) charting the course of the disease. The source of the virus was thought to be the patient's child. Empirical treatment with oral corticosteroids was commenced and the inflammation resolved, leaving a residual macular scar.

conclusionsWe present this case combined with the review of literature of adult onset Coxsackie-virus-associated retinitis. This case reiterates the fact that Coxsackie virus is an uncommon but important consideration in the differential diagnosis of chorioretinitis and posterior uveitis with atypical retinopathy.

Indexed as

Acute maculopathyAutofluorescenceCoxsackie virusfoot and mouth disease (HFMD)HandPosterior uveitis

Identifiers

PMID25774239
PMCPMC4333364
OpenAlexW2146527364

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.