ArticleCrystal growth & design2015
Continuous Crystallization of Proteins in a Tubular Plug-Flow Crystallizer.
Article in Crystal growth & design, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Technical Scale in Biomolecular Crystallization.Advances in biochemical engineering/biotechnology · 2026Review
- Flow as a Control Strategy to Promote Biomolecule Nucleation.Advances in biochemical engineering/biotechnology · 2026Review
- Continuous Crystallization Platforms to Crystallize Biomolecules.Advances in biochemical engineering/biotechnology · 2026Review
- In-drop thermal cycling of microcrystal assembly for senescence control (MASC) with minimal variation in efficacy.Advanced functional materials · 2023Article
- Antisolvent Crystallization of Telmisartan Using Stainless-Steel Micromixing Membrane Contactors.Crystal growth & design · 2023Article
- Strategy for Fast Decision on Material System Suitability for Continuous Crystallization Inside a Slug Flow Crystallizer.Micromachines · 2022Article
- Design of a Combined Modular and 3D-Printed Falling Film Solution Layer Crystallizer for Intermediate Purification in Continuous Production of Pharmaceuticals.Industrial & engineering chemistry research · 2021Article
- Production of Cross-Linked Lipase Crystals at a Preparative Scale.Crystal growth & design · 2021Article
- Crystal Shape Modification via Cycles of Growth and Dissolution in a Tubular Crystallizer.Crystal growth & design · 2018Article
- Crystal Engineering in Continuous Plug-Flow Crystallizers.Crystal growth & design · 2017Article
- Mass spectrometric directed system for the continuous-flow synthesis and purification of diphenhydramine.Chemical science · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein crystals have many important applications in many fields, including pharmaceutics. Being more stable than other formulations, and having a high degree of purity and bioavailability, they are especially promising in the area of drug delivery. In this contribution, the development of a continuously operated tubular crystallizer for the production of protein crystals has been described. Using the model enzyme lysozyme, we successfully generated product particles ranging between 15 and 40 μm in size. At the reactor inlet, a protein solution was mixed with a crystallization agent solution to create high supersaturations required for nucleation. Along the tube, supersaturation was controlled using water baths that divided the crystallizer into a nucleation zone and a growth zone. Low flow rates minimized the effect of shear forces that may impede crystal growth. Simultaneously, a slug flow was implemented to ensure crystal transport through the reactor and to reduce the residence time distribution.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.