Evidence map›Paper›PMID 25774080›Full record

ReviewIn vitro cellular & developmental biology. Plant : journal of the Tissue Culture Association

Genome editing in plants via designed zinc finger nucleases.

Joseph F Petolino

Abstract readReview
In one paragraph

Review in In vitro cellular & developmental biology. Plant : journal of the Tissue Culture Association. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

  1. Article
  2. RNAi and genome editing of sugarcane: Progress and prospects.The Plant journal : for cell and molecular biology · 2025
    Review
  3. Article
  4. Review
  5. Recent Advances in Tomato Gene Editing.International journal of molecular sciences · 2024
    Review
  6. Review
  7. Article
  8. Review
  9. Zinc binding of a Cys2His2-type zinc finger protein is enhanced by the interaction with DNA.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2023
    Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. CRISPR/Cas9-Mediated Mutagenesis ofInternational journal of molecular sciences · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Joseph F PetolinoDow AgroSciences, 9330 Zionsville Rd., Indianapolis, IN USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ability to create DNA double-strand breaks (DSBs) at specified genomic locations, which then stimulate the cell's naturally occurring DNA repair processes, has introduced intriguing possibilities for genetic modification. Zinc finger nucleases (ZFNs) are designed restriction enzymes consisting of a nonspecific cleavage domain fused to sequence-specific DNA binding domains. ZFN-mediated DSB formation at endogenous genomic loci followed by error-prone non-homologous end joining (NHEJ) repair can result in gene-specific mutations

Indexed as

Designed nucleasesDNA repairGene targetingSite-specific transgene integrationTargeted mutagenesis

Identifiers

PMID25774080
PMCPMC4352198

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.