Evidence map›Paper›PMID 25773931›Full record

ArticleTicks and tick-borne diseases2015

High prevalence of "Candidatus Rickettsia andeanae" and apparent exclusion of Rickettsia parkeri in adult Amblyomma maculatum (Acari: Ixodidae) from Kansas and Oklahoma.

Christopher D Paddock, Amy M Denison, Michael W Dryden, Bruce H Noden, R Ryan Lash, Sarah S Abdelghani, Anna E Evans, Aubree R Kelly, Joy A Hecht, Sandor E Karpathy and 2 more

Open access · greenAbstract read
In one paragraph

Article in Ticks and tick-borne diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 68 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Spotted Fever GroupInsects · 2024
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  6. 'Pathogens (Basel, Switzerland) · 2023
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  8. Brown Dog Tick (International journal of environmental research and public health · 2022
    Article
  9. Four Tick-Borne Microorganisms and Their Prevalence inPathogens (Basel, Switzerland) · 2021
    Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. TheFrontiers in veterinary science · 2021
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Spotted Fever GroupInfection and immunity · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Christopher D PaddockRickettsial Zoonoses Branch, Centers for Disease Control and Prevention, Atlanta, GA, United States. Electronic address: CPaddock@cdc.gov.
Amy M DenisonInfectious Diseases Pathology Branch, Centers for Disease Control and Prevention, Atlanta, GA, United States.
Michael W DrydenDepartment of Diagnostic Medicine and Pathobiology, Kansas State University, KS, United States.
Bruce H NodenDepartment of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK, United States.
R Ryan LashTravelers' Health Branch, Centers for Disease Control and Prevention, Atlanta, GA, United States.
Sarah S AbdelghaniQuillen College of Medicine, East Tennessee State University, Johnson City, TN, United States.
Anna E EvansNell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, United States.
Aubree R KellyBacterial Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA, United States.
Joy A HechtRickettsial Zoonoses Branch, Centers for Disease Control and Prevention, Atlanta, GA, United States.
Sandor E KarpathyRickettsial Zoonoses Branch, Centers for Disease Control and Prevention, Atlanta, GA, United States.
Roman R GantaDepartment of Diagnostic Medicine and Pathobiology, Kansas State University, KS, United States.
Susan E LittleVeterinary Pathobiology, Oklahoma State University, Stillwater, OK, United States.
Centers for Disease Control and Prevention · USKansas State University · USOklahoma State University · USEast Tennessee State University · USEmory University · US

Funding

Vector and Host Contributions to the Regulation of E. Chaffeensis Gene ExpressionR01AI070908 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI ROMAN R. GANTA · 2008 to 2026
$6.9M
NIAID NIH HHS R01 AI070908
6 · The paper itself

Abstract

Amblyomma maculatum (the Gulf Coast tick), an aggressive, human-biting, Nearctic and Neotropical tick, is the principal vector of Rickettsia parkeri in the United States. This pathogenic spotted fever group Rickettsia species has been identified in 8-52% of questing adult Gulf Coast ticks in the southeastern United States. To our knowledge, R. parkeri has not been reported previously from adult specimens of A. maculatum collected in Kansas or Oklahoma. A total of 216 adult A. maculatum ticks were collected from 18 counties in Kansas and Oklahoma during 2011-2014 and evaluated by molecular methods for evidence of infection with R. parkeri. No infections with this agent were identified; however, 47% of 94 ticks collected from Kansas and 73% of 122 ticks from Oklahoma were infected with "Candidatus Rickettsia andeanae" a spotted fever group Rickettsia species of undetermined pathogenicity. These preliminary data suggest that "Ca. R. andeanae" is well-adapted to survival in populations of A. maculatum in Kansas and Oklahoma, and that its ubiquity in Gulf Coast ticks in these states may effectively exclude R. parkeri from their shared arthropod host, which could diminish markedly or preclude entirely the occurrence of R. parkeri rickettsiosis in this region of the United States.

Indexed as

AnimalsArachnid VectorsFemaleHumansIxodidaeKansasMaleOklahomaPrevalenceRickettsiaRickettsia InfectionsAmblyomma maculatum“Candidatus Rickettsia andeanae”Rickettsial interferenceRickettsia parkeri

Identifiers

PMID25773931
PMCPMC4487539
OpenAlexW1964988538

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.