Evidence map›Paper›PMID 25773660›Full record

ReviewRheumatology international2015

TGF-β signal transduction pathways and osteoarthritis.

Guangju Zhai, Jules Doré, Proton Rahman

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Rheumatology international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03665116 (Effects of Arginine on Osteoarthritis), which is not on this map. Cited by 47 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03665116 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Effects of Arginine on Osteoarthritis: A Pilot Clinical Trial

TypeinterventionalSponsorMemorial University of NewfoundlandRan2019 to 2024Enrolled38ConditionsKnee OsteoarthritisArmsL-arginine
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Guangju ZhaiDiscipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Canada, guangju.zhai@med.mun.ca.
Jules Doré
Proton Rahman
Memorial University of Newfoundland · CA

Funding

Canadian Institutes of Health Research
6 · The paper itself

Abstract

Osteoarthritis (OA) is the most common form of arthritis, resulting in substantial disability and economic burden worldwide. While its exact pathogenesis remains elusive, both in vitro and human population-based studies have merged to support the hypothesis that TGF-β/BMP-mediated signalling pathways play a role in the development of OA. Unraveling the TGF-β/BMP-mediated mechanism(s) in OA has great potential in identifying novel targets and developing new drugs for OA treatment. This review summarizes both in vitro and in vivo evidence of TGF-β/BMP-mediated signal transduction pathways in OA and discusses the future research direction in this regard.

Indexed as

Bone and BonesBone Morphogenetic ProteinsCartilage, ArticularChondrocytesHumansOsteoarthritisOsteoblastsSignal TransductionSmad ProteinsTransforming Growth Factor betaBone Morphogenetic ProteinsSmad ProteinsTransforming Growth Factor beta

Identifiers

PMID25773660
OpenAlexW2058894658

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.