ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2015
Evaluating changes in tendon crimp with fatigue loading as an ex vivo structural assessment of tendon damage.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- Collagen Mechanics.Sub-cellular biochemistry · 2026Review
- Assessment of Mechanically Induced Changes in Helical Fiber Microstructure Using Diffusion Tensor Imaging.Annals of biomedical engineering · 2024Article
- Direct measurements of collagen fiber recruitment in the posterior pole of the eye.Acta biomaterialia · 2024Article
- Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity.Nature biomedical engineering · 2022Article
- Nonsurgical treatment reduces tendon inflammation and elevates tendon markers in early healing.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Tendinopathy and tendon material response to load: What we can learn from small animal studies.Acta biomaterialia · 2021Review
- Mechanical properties of the different rotator cuff tendons in the rat are similarly and adversely affected by age.Journal of biomechanics · 2021Article
- Accumulation of collagen molecular unfolding is the mechanism of cyclic fatigue damage and failure in collagenous tissues.Science advances · 2020Article
- Tendon Biomechanics and Crimp Properties Following Fatigue Loading Are Influenced by Tendon Type and Age in Mice.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- Multi-Scale Loading and Damage Mechanisms of Plantaris and Rat Tail Tendons.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019Article
- Effects of immobilization angle on tendon healing after achilles rupture in a rat model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019Article
- Dynamic Loading and Tendon Healing Affect Multiscale Tendon Properties and ECM Stress Transmission.Scientific reports · 2018Article
- Tendon healing affects the multiscale mechanical, structural and compositional response of tendon to quasi-static tensile loading.Journal of the Royal Society, Interface · 2018Article
- Freezing does not alter multiscale tendon mechanics and damage mechanisms in tension.Annals of the New York Academy of Sciences · 2017Article
- Crimped Nanofibrous Biomaterials Mimic Microstructure and Mechanics of Native Tissue and Alter Strain Transfer to Cells.ACS biomaterials science & engineering · 2017Article
- Temporal Healing of Achilles Tendons After Injury in Rodents Depends on Surgical Treatment and Activity.The Journal of the American Academy of Orthopaedic Surgeons · 2017Article
- Investigating mechanisms of tendon damage by measuring multi-scale recovery following tensile loading.Acta biomaterialia · 2017Article
- Mechanical, histological, and functional properties remain inferior in conservatively treated Achilles tendons in rodents: Long term evaluation.Journal of biomechanics · 2017Article
- Nonsurgical treatment and early return to activity leads to improved Achilles tendon fatigue mechanics and functional outcomes during early healing in an animal model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2016Article
- Postinjury biomechanics of Achilles tendon vary by sex and hormone status.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The complex structure of tendons relates to their mechanical properties. Previous research has associated the waviness of collagen fibers (crimp) during quasi-static tensile loading to tensile mechanical properties, but less is known about the role of fatigue loading on crimp properties. In this study (IACUC approved), mouse patellar tendons were fatigue loaded while an integrated plane polariscope simultaneously assessed crimp properties. We demonstrate a novel structural mechanism whereby tendon crimp amplitude and frequency are altered with fatigue loading. In particular, fatigue loading increased the crimp amplitude across the tendon width and length, and these structural alterations were shown to be both region and load dependent. The change in crimp amplitude was strongly correlated to mechanical tissue laxity (defined as the ratio of displacement and gauge length relative to the first cycle of fatigue loading assessed at constant load throughout testing), at all loads and regions evaluated. Together, this study highlights the role of fatigue loading on tendon crimp properties as a function of load applied and region evaluated, and offers an additional structural mechanism for mechanical alterations that may lead to ultimate tendon failure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.