ArticleNeuropsychology review2015
Genetics and brain morphology.
Article in Neuropsychology review, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Genetic Influences on the Developing Young Brain and Risk for Neuropsychiatric Disorders.Biological psychiatry · 2023Pooled it
- Gray matter volume alterations in subjects with overweight and obesity: Evidence from a voxel-based meta-analysis.Frontiers in psychiatry · 2022Pooled it
- Neuroanatomical differences in obesity: meta-analytic findings and their validation in an independent dataset.International journal of obesity (2005) · 2019Pooled it
- Heritability of gray matter volume and asymmetry in chimpanzees (Pan troglodytes) and their association to cognitive abilities and tool use.Brain structure & function · 2025Article
- Polygenic risk scores and brain structures both contribute to externalizing behavior in childhood - A study in the Adolescent Brain and Cognitive Development (ABCD) cohort.Neuroscience applied · 2023Article
- Multivariate Genetic Structure of Externalizing Behavior and Structural Brain Development in a Longitudinal Adolescent Twin Sample.International journal of molecular sciences · 2022Article
- Human Connectome Project: heritability of brain volumes in young healthy adults.Experimental brain research · 2021Article
- Examining Individual Differences in Language Learning: A Neurocognitive Model of Language Aptitude.Neurobiology of language (Cambridge, Mass.) · 2021Article
- Inferring the heritability of large-scale functional networks with a multivariate ACE modeling approach.Network neuroscience (Cambridge, Mass.) · 2021Article
- Genetic Contributions to Multivariate Data-Driven Brain Networks Constructed via Source-Based Morphometry.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Further evidence of a left hemisphere specialization and genetic basis for tool use skill in chimpanzees (Pan troglodytes): Reproducibility in two genetically isolated populations of apes.Journal of comparative psychology (Washington, D.C. : 1983) · 2019Article
- Heritability of Gray Matter Structural Covariation and Tool Use Skills in Chimpanzees (Pan troglodytes): A Source-Based Morphometry and Quantitative Genetic Analysis.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- DRD2 methylation and regional grey matter volumes in young adult offspring from families at ultra-high risk for alcohol dependence.Psychiatry research. Neuroimaging · 2019Article
- Predicting age from cortical structure across the lifespan.The European journal of neuroscience · 2018Article
- Genome-wide association analysis identifies common variants influencing infant brain volumes.Translational psychiatry · 2017Article
- Imaging genetics in neurodevelopmental psychopathology.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017Review
- Genetic and environmental influences on mean diffusivity and volume in subcortical brain regions.Human brain mapping · 2017Article
- Heritability of white matter microstructure in late middle age: A twin study of tract-based fractional anisotropy and absolute diffusivity indices.Human brain mapping · 2017Article
- Advances in Studying Brain Morphology: The Benefits of Open-Access Data.Frontiers in human neuroscience · 2017Article
- Conservation of Distinct Genetically-Mediated Human Cortical Pattern.PLoS genetics · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
A wealth of empirical evidence is accumulating on the genetic mediation of brain structure phenotypes. This comes from twin studies that assess heritability and genetic covariance between traits, candidate gene associations, and genome-wide association studies (GWAS) that can identify specific genetic variants. Here we review the major findings from each of these approaches and consider how they inform on the genetic architecture of brain structure. The findings from twin studies show there is a strong genetic influence (heritability) on brain structure, and overlap of genetic effects (pleiotropy) between structures, and between structure and cognition. However, there is also evidence for genetic specificity, with distinct genetic effects across some brain regions. Candidate gene associations show little convergence; most have been under powered to detect effect sizes of the magnitude now expected. GWAS have identified 19 genetic variants for brain structure, though no replicated associations account for more than 1% of the variance. Together these studies are revealing new insights into the genetic architecture of brain morphology. As the scope of inquiry broadens, including measures that capture the complexity of the brain, along with larger samples and new analyses, such as genome-wide common trait analysis (GCTA) and polygenic scores, which combine variant effects for a phenotype, as well as whole-genome sequencing, more genetic variants for brain structure will be identified. Increasingly, large-scale multi-site studies will facilitate this next wave of studies, and promise to enhance our understanding of the etiology of variation in brain morphology, as well as brain disorders.
Indexed as
Identifiers
25773500What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.