Evidence map›Paper›PMID 25773499›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2015

Center-Level Experience and Kidney Transplant Outcomes in HIV-Infected Recipients.

J E Locke, R D Reed, S G Mehta, C Durand, R B Mannon, P MacLennan, B Shelton, M Y Martin, H Qu, R Shewchuk and 1 more

Abstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Pretransplant CD4 Count Influences Immune Reconstitution and Risk of Infectious Complications in Human Immunodeficiency Virus-Infected Kidney Allograft Recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2016
    Trial
  3. Review
  4. Article
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  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Solid Organ Transplantation for HIV-Infected Individuals.Current treatment options in infectious diseases · 2018
    Article
  15. Article
  16. Barriers to listing for HIV-infected patients being evaluated for kidney transplantation.Transplant infectious disease : an official journal of the Transplantation Society · 2017
    Article
  17. Serum creatinine elevation after switch to dolutegravir in a human immunodeficiency virus-positive kidney transplant recipient.Transplant infectious disease : an official journal of the Transplantation Society · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

J E LockeDepartment of Surgery, Division of Transplantation, University of Alabama at Birmingham, Birmingham, AL.
R D ReedDepartment of Surgery, Division of Transplantation, University of Alabama at Birmingham, Birmingham, AL.
S G MehtaDepartment of Medicine, Division of Transplant Nephrology, University of Alabama at Birmingham, Birmingham, AL.
C DurandDepartment of Medicine, Division of Infectious Disease, Johns Hopkins Medical Institutions, Baltimore, MD.
R B MannonDepartment of Medicine, Division of Transplant Nephrology, University of Alabama at Birmingham, Birmingham, AL.
P MacLennanDepartment of Surgery, Division of Transplantation, University of Alabama at Birmingham, Birmingham, AL.
B SheltonDepartment of Surgery, Division of Transplantation, University of Alabama at Birmingham, Birmingham, AL.
M Y MartinDepartment of Medicine, Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL.
H QuDepartment of Health Services Administration, University of Alabama at Birmingham School of Health Professions, Birmingham, AL.
R ShewchukDepartment of Health Services Administration, University of Alabama at Birmingham School of Health Professions, Birmingham, AL.
D L SegevDepartment of Medicine, Division of Infectious Disease, Johns Hopkins Medical Institutions, Baltimore, MD.

Funding

Patient Oriented Research in Kidney Disease and Transplant SurgeryK24DK101828 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2014 to 2018
$922k
NIDDK NIH HHS K24 DK101828NIDDK NIH HHS K24DK101828
6 · The paper itself

Abstract

Excellent outcomes among HIV+ kidney transplant (KT) recipients have been reported by the NIH consortium, but it is unclear if experience with HIV+ KT is required to achieve these outcomes. We studied associations between experience measures and outcomes in 499 HIV+ recipients (SRTR data 2004-2011). Experience measures examined included: (1) center-level participation in the NIH consortium; (2) KT experiential learning curve; and (3) transplant era (2004-2007 vs. 2008-2011). There was no difference in outcomes among centers early in their experience (first 5 HIV+ KT) compared to centers having performed >6 HIV+ KT (GS adjusted hazard ratio [aHR]: 1.05, 95% CI: 0.68-1.61, p = 0.82; PS aHR: 0.93; 95% CI: 0.56-1.53, p = 0.76), and participation in the NIH-study was not associated with any better outcomes (GS aHR: 1.08, 95% CI: 0.71-1.65, p = 0.71; PS aHR: 1.13; 95% CI: 0.68-1.89, p = 0.63). Transplant era was strongly associated with outcomes; HIV+ KTs performed in 2008-2011 had 38% lower risk of graft loss (aHR: 0.62; 95% CI: 0.42-0.92, p = 0.02) and 41% lower risk of death (aHR: 0.59; 95% CI: 0.39-0.90, p = 0.01) than that in 2004-2007. Outcomes after HIV+ KT have improved over time, but center-level experience or consortium participation is not necessary to achieve excellent outcomes, supporting continued expansion of HIV+ KT in the US.

Indexed as

Kidney TransplantationAdolescentAdultAgedHIV InfectionsHumansMiddle AgedUnited StatesYoung Adultclinical research/practicegraft survivalhealth services and outcomes researchinfection and infectious agentsinfectious diseasekidney (allograft) function/dysfunctionkidney transplantation/nephrologypatient survivalScientific Registry for Transplant Recipients(SRTR)viral: human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS)

Identifiers

PMID25773499
PMCPMC5933060

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.