ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2015
Correlation of microRNA-10b upregulation and poor prognosis in human gliomas.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Prognostic Significance of MicroRNAs in Glioma: A Systematic Review and Meta-Analysis.BioMed research international · 2019Pooled it
- Engineered smart materials for RNA based molecular therapy to treat Glioblastoma.Bioactive materials · 2024Article
- Upregulated miR-10b-5p as a potential miRNA signature in amyotrophic lateral sclerosis patients.Frontiers in cellular neuroscience · 2024Article
- Identification and Potential Mechanisms of a 7-MicroRNA Signature That Predicts Prognosis in Patients with Lower-Grade Glioma.Journal of healthcare engineering · 2021Article
- The miRNA Content of Exosomes Released from the Glioma Microenvironment Can Affect Malignant Progression.Biomedicines · 2020Article
- A five-microRNA signature for individualized prognosis evaluation and radiotherapy guidance in patients with diffuse lower-grade glioma.Journal of cellular and molecular medicine · 2020Article
- Stepwise detection and evaluation reveal miR-10b and miR-222 as a remarkable prognostic pair for glioblastoma.Oncogene · 2019Article
- MicroRNA-10b-5p downregulation inhibits the invasion of glioma cells via modulating homeobox B3 expression.Experimental and therapeutic medicine · 2019Article
- In silico analysis identified miRNA‑based therapeutic agents against glioblastoma multiforme.Oncology reports · 2019Article
- Downregulation of microRNA-374a predicts poor prognosis in human glioma.Experimental and therapeutic medicine · 2019Article
- SIRP Alpha Protein Downregulates in Human Astrocytoma: Presumptive Involvement of Hsa-miR-520d-5p and Hsa-miR-520d-3p.Molecular neurobiology · 2017Article
- MicroRNA-10b inhibits proliferation, migration and invasion in cervical cancer cells via direct targeting of insulin-like growth factor-1 receptor.Oncology letters · 2017Article
- Expression and prognostic value of microRNAs in lower-grade glioma depends on IDH1/2 status.Journal of neuro-oncology · 2017Article
- Low MiR-149 expression is associated with unfavorable prognosis and enhanced Akt/mTOR signaling in glioma.International journal of clinical and experimental pathology · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to detect the association between the microRNA-10b (miR-10b) expression level and prognosis in glioma patients. Quantitative real-time polymerase chain reaction (qRT-PCR) analysis was used to measure the expression of miR-10b levels in different-grade glioma tissues and normal brain tissues. The relationship between miR-10b expression levels and clinical pathological characteristics was statistically analyzed. The influence of miR-10b on survival of glioma patients was also analyzed. As a result, miR-10b expression levels in glioma tissues were significantly increased compared to those of normal brain tissues (p < 0.001). And the increased expression levels were associated with the advanced glioma grade (p < 0.001) and larger tumor size (p < 0.001). Moreover, the results of the Kaplan-Meier survival curve indicated that overall survival (OS) and progression-free survival (PFS) were significantly poorer in the high-expression-level group than those in the low-expression-level group (p < 0.001). Finally, the results of the multivariate Cox regression model indicated that the miR-10b expression level was an independent prognostic factor for glioma patients. Taken together, these findings offer convincing evidence that increased miR-10b expression may be an independent marker to predict poor prognosis in patients with gliomas.
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