ReviewMedical & biological engineering & computing2015
Isolated heart models: cardiovascular system studies and technological advances.
Review in Medical & biological engineering & computing, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Presentation of preload and afterload to isolated heart preparations.The Journal of physiology · 2026Review
- Membrane Oxygenation Improves Functional Myocardial Preservation and Enables Colloid-Enriched Perfusion in the Langendorff Isolated Heart Model.Medical sciences (Basel, Switzerland) · 2026Article
- A Closed Circulation Langendorff Heart Perfusion Method for Cardiac Drug Screening.Physiological research · 2024Article
- Electrical remodeling of atrioventricular junction: a study on retrogradely perfused chick embryonic heart.American journal of physiology. Heart and circulatory physiology · 2024Article
- Liraglutide Pretreatment Does Not Improve Acute Doxorubicin-Induced Cardiotoxicity in Rats.International journal of molecular sciences · 2024Article
- Long-termCurrent research in physiology · 2023Article
- Modified Technique for the Use of Neonatal Murine Hearts in the Langendorff Preparation.Journal of visualized experiments : JoVE · 2022Article
- Assessment of Cardiac Toxicity of Manganese Chloride for Cardiovascular Magnetic Resonance.Frontiers in physiology · 2022Article
- Basic Research Approaches to Evaluate Cardiac Arrhythmia in Heart Failure and Beyond.Frontiers in physiology · 2022Review
- Golden Standard or Obsolete Method? Review of ECG Applications in Clinical and Experimental Context.Frontiers in physiology · 2022Review
- Cardioprotective action of aprepitant in a rat model of ischemia-reperfusioninduced myocardial injury: role of PI3K-AkT-GSK-3β-HIF-1α signaling pathway.Acta cirurgica brasileira · 2022Article
- Model Systems for Addressing Mechanism of Arrhythmogenesis in Cardiac Repair.Current cardiology reports · 2021Review
- Strategies for targeting the cardiac sarcomere: avenues for novel drug discovery.Expert opinion on drug discovery · 2020Review
- Mechanism of the hypoxia inducible factor 1/hypoxic response element pathway in rat myocardial ischemia/diazoxide post‑conditioning.Molecular medicine reports · 2020Article
- Article
- Experimental models of cardiac physiology and pathology.Heart failure reviews · 2019Review
- Exercise and Cardioprotection: A Natural Defense Against Lethal Myocardial Ischemia-Reperfusion Injury and Potential Guide to Cardiovascular Prophylaxis.Journal of cardiovascular pharmacology and therapeutics · 2019Review
- Humanizing Miniature Hearts through 4-Flow Cannulation Perfusion Decellularization and Recellularization.Scientific reports · 2018Article
- Effect of increased left ventricle mass on ischemia assessment in electrocardiographic signals: rabbit isolated heart study.BMC cardiovascular disorders · 2017Article
- DS16570511 is a small-molecule inhibitor of the mitochondrial calcium uniporter.Cell death discovery · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Isolated heart model is a relevant tool for cardiovascular system studies. It represents a highly reproducible model for studying broad spectrum of biochemical, physiological, morphological, and pharmaceutical parameters, including analysis of intrinsic heart mechanics, metabolism, and coronary vascular response. Results obtained in this model are under no influence of other organ systems, plasma concentration of hormones or ions and influence of autonomic nervous system. The review describes various isolated heart models, the modes of heart perfusion, and advantages and limitations of various experimental setups. It reports the improvements of perfusion setup according to Langendorff introduced by the authors.
Indexed as
Identifiers
25773369What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.