ArticleDevelopmental biology2015
Hydroxyurea-mediated neuroblast ablation establishes birth dates of secondary lineages and addresses neuronal interactions in the developing Drosophila brain.
Article in Developmental biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Article
- Nucleolar stress inBiology open · 2020Article
- Article
- Developmentally Arrested Precursors of Pontine Neurons Establish an Embryonic Blueprint of the Drosophila Central Complex.Current biology : CB · 2019Article
- Neuronal Constituents and Putative Interactions Within theFrontiers in neural circuits · 2018Article
- Structure and development of the subesophageal zone of the Drosophila brain. I. Segmental architecture, compartmentalization, and lineage anatomy.The Journal of comparative neurology · 2018Article
- Development of the anterior visual input pathway to the Drosophila central complex.The Journal of comparative neurology · 2017Article
- A conserved plan for wiring up the fan-shaped body in the grasshopper and Drosophila.Development genes and evolution · 2017Article
- Developmental analysis of the dopamine-containing neurons of the Drosophila brain.The Journal of comparative neurology · 2017Article
- Gap junction networks in mushroom bodies participate in visual learning and memory in Drosophila.eLife · 2016Article
- Patterns of growth and tract formation during the early development of secondary lineages in the Drosophila larval brain.Developmental neurobiology · 2016Article
- Lineage-associated tracts defining the anatomy of the Drosophila first instar larval brain.Developmental biology · 2015Article
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2 authors at 1 institution in 1 country.
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Abstract
The Drosophila brain is comprised of neurons formed by approximately 100 lineages, each of which is derived from a stereotyped, asymmetrically dividing neuroblast. Lineages serve as structural and developmental units of Drosophila brain anatomy and reconstruction of lineage projection patterns represents a suitable map of Drosophila brain circuitry at the level of neuron populations ("macro-circuitry"). Two phases of neuroblast proliferation, the first in the embryo and the second during the larval phase (following a period of mitotic quiescence), produce primary and secondary lineages, respectively. Using temporally controlled pulses of hydroxyurea (HU) to ablate neuroblasts and their corresponding secondary lineages during the larval phase, we analyzed the effect on development of primary and secondary lineages in the late larval and adult brain. Our findings indicate that timing of neuroblast re-activation is highly stereotyped, allowing us to establish "birth dates" for all secondary lineages. Furthermore, our results demonstrate that, whereas the trajectory and projection pattern of primary and secondary lineages is established in a largely independent manner, the final branching pattern of secondary neurons is dependent upon the presence of appropriate neuronal targets. Taken together, our data provide new insights into the degree of neuronal plasticity during Drosophila brain development.
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