ArticleJournal of bioenergetics and biomembranes2015
Cysteine dietary supplementation reverses the decrease in mitochondrial ROS production at complex I induced by methionine restriction.
Article in Journal of bioenergetics and biomembranes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Tissue-specific molecular regulation of aging mechanisms with methionine restriction in mice and the potential role of methionine sulfoxide reductase.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Aging and Alzheimer's: the critical role of mitochondrial dysfunction and synaptic alterations.Frontiers in synaptic neuroscience · 2025Review
- Dietary methionine restriction in cancer development and antitumor immunity.Trends in endocrinology and metabolism: TEM · 2024Review
- Sulfur Amino Acid Restriction alters mitochondrial function depending on tissue, sex, and Methionine sulfoxide reductase A (MsrA) status.Research square · 2023Article
- Dietary Manipulation of Amino Acids for Cancer Therapy.Nutrients · 2023Review
- Dietary Methionine and Total Sulfur Amino Acid Restriction in Healthy Adults.The journal of nutrition, health & aging · 2023Article
- Metabolic benefits of methionine restriction in adult mice do not require functional methionine sulfoxide reductase A (MsrA).Scientific reports · 2022Article
- Targeting the methionine addiction of cancer.American journal of cancer research · 2022Review
- Extracellular cystine influences human preadipocyte differentiation and correlates with fat mass in healthy adults.Amino acids · 2021Article
- Plasma methionine metabolic profile is associated with longevity in mammals.Communications biology · 2021Article
- High-Fat Diet Alleviates Neuroinflammation and Metabolic Disorders of APP/PS1 Mice and the Intervention With Chinese Medicine.Frontiers in aging neuroscience · 2021Article
- The Advanced Lipoxidation End-Product Malondialdehyde-Lysine in Aging and Longevity.Antioxidants (Basel, Switzerland) · 2020Review
- Gene expression and regulatory factors of the mechanistic target of rapamycin (mTOR) complex 1 predict mammalian longevity.GeroScience · 2020Article
- Low abundance of NDUFV2 and NDUFS4 subunits of the hydrophilic complex I domain and VDAC1 predicts mammalian longevity.Redox biology · 2020Article
- The road ahead for health and lifespan interventions.Ageing research reviews · 2020Review
- Methionine Restriction and Cancer Biology.Nutrients · 2020Review
- Succination of Protein Thiols in Human Brain Aging.Frontiers in aging neuroscience · 2020Review
- Nutritional Regulation of Gene Expression: Carbohydrate-, Fat- and Amino Acid-Dependent Modulation of Transcriptional Activity.International journal of molecular sciences · 2019Review
- Regulation of metabolic health by essential dietary amino acids.Mechanisms of ageing and development · 2019Review
- Cutting back on the essentials: Can manipulating intake of specific amino acids modulate health and lifespan?Ageing research reviews · 2017Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been described that dietary cysteine reverses many of the beneficial changes induced by methionine restriction in aging rodents. In this investigation male Wistar rats were subjected to diets low in methionine, supplemented with cysteine, or simultaneously low in methionine and supplemented with cysteine. The results obtained in liver showed that cysteine supplementation reverses the decrease in mitochondrial ROS generation induced by methionine restriction at complex I. Methionine restriction also decreased various markers of oxidative and non-oxidative stress on mitochondrial proteins which were not reversed by cysteine. Instead, cysteine supplementation also lowered protein damage in association with decreases in mTOR activation. The results of the present study add the decrease in mitochondrial ROS production to the various beneficial changes induced by methionine restriction that are reversed by cysteine dietary supplementation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.