ArticleJournal of materials science. Materials in medicine2015
Pluronic F-127 hydrogel as a promising scaffold for encapsulation of dental-derived mesenchymal stem cells.
Article in Journal of materials science. Materials in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
72 citing papers in PubMed, 220 citations in OpenAlex.
- The Osteoimmunologic Basis of Biologic and Bioengineered Therapies in Osteoarthritis.Biomedicines · 2026Review
- Thermogelation of polymer nanoassemblies: promising platforms for injectable biomaterials in medical applications.Nanomedicine (London, England) · 2026Review
- Development of a gene-activated matrix for enhanced AAV gene deliveryFrontiers in bioengineering and biotechnology · 2026Article
- Elastomeric PU-Pluronic F‑127 Thin Films: Catalyst and Solvent Effects on Microstructure, Mechanical Properties, and Biocompatibility.ACS omega · 2025Article
- Radiation-Sensitive Nano-, Micro-, and Macro-Gels and Polymer Capsules for Use in Radiotherapy Dosimetry.International journal of molecular sciences · 2025Article
- Are Black Phosphorus Hydrogels Antimicrobial Without Photonic Activation?Molecules (Basel, Switzerland) · 2025Article
- Hydrogel-Based Bioinks for Coaxial and Triaxial Bioprinting: A Review of Material Properties, Printing Techniques, and Applications.Polymers · 2025Review
- The Effects of Encapsulating Bioactive Irish Honey into Pluronic-Based Thermoresponsive Hydrogels and Potential Application in Soft Tissue Regeneration.Gels (Basel, Switzerland) · 2025Article
- Synergistic Effect of Polydeoxyribonucleotides with Low-Level Lasers on the Regeneration of Crush-Injured Facial Nerves.Journal of clinical medicine · 2025Article
- Development of a 3D printed liquid-core hydrogel platform for real-time carbon nanotube sensors.Emergent materials · 2025Article
- Fabrication of metal complex phthalocyanine and porphyrin nanoparticle aqueous colloids by pulsed laser fragmentation in liquid and their potential application to a photosensitizer for photodynamic therapy.Beilstein journal of nanotechnology · 2025Article
- Balancing sterilization and functional properties in Poloxamer 407 hydrogels: comparing heat and radiation techniques.Regenerative biomaterials · 2025Article
- Recent advances and applications of artificial intelligence in 3D bioprinting.Biophysics reviews · 2024Review
- Fabrication of Two-Layer Microfluidic Devices with Porous Electrodes Using Printed Sacrificial Layers.Micromachines · 2024Article
- Synthetic and Natural Biomaterials in Veterinary Medicine and Ophthalmology: A Review of Clinical Cases and Experimental Studies.Veterinary sciences · 2024Review
- Integrated In Vivo and In Vitro Evaluation of a Powder-to-Hydrogel, Film-Forming Polymer Complex Base with Tissue-Protective and Microbiome-Supportive Properties.Gels (Basel, Switzerland) · 2024Article
- Incorporation of Resveratrol-Hydroxypropyl-β-Cyclodextrin Complexes into Hydrogel Formulation for Wound Treatment.Gels (Basel, Switzerland) · 2024Article
- Article
- Local Spinal Cord Injury Treatment Using a Dental Pulp Stem Cell Encapsulated HAdvanced healthcare materials · 2024Article
- On the Use of the Fricke-Pluronic F-127 Gel Dosimeter for Radiation Isocenter Testing of a Medical Linear Accelerator.Materials (Basel, Switzerland) · 2024Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Dental-derived mesenchymal stem cells (MSCs) provide an advantageous therapeutic option for tissue engineering due to their high accessibility and bioavailability. However, delivering MSCs to defect sites while maintaining a high MSC survival rate is still a critical challenge in MSC-mediated tissue regeneration. Here, we tested the osteogenic and adipogenic differentiation capacity of dental pulp stem cells (DPSCs) in a thermoreversible Pluronic F127 hydrogel scaffold encapsulation system in vitro. DPSCs were encapsulated in Pluronic (®) F-127 hydrogel and stem cell viability, proliferation and differentiation into adipogenic and osteogenic tissues were evaluated. The degradation profile and swelling kinetics of the hydrogel were also analyzed. Our results confirmed that Pluronic F-127 is a promising and non-toxic scaffold for encapsulation of DPSCs as well as control human bone marrow MSCs (hBMMSCs), yielding high stem cell viability and proliferation. Moreover, after 2 weeks of differentiation in vitro, DPSCs as well as hBMMSCs exhibited high levels of mRNA expression for osteogenic and adipogenic gene markers via PCR analysis. Our histochemical staining further confirmed the ability of Pluronic F-127 to direct the differentiation of these stem cells into osteogenic and adipogenic tissues. Furthermore, our results revealed that Pluronic F-127 has a dense tubular and reticular network morphology, which contributes to its high permeability and solubility, consistent with its high degradability in the tested conditions. Altogether, our findings demonstrate that Pluronic F-127 is a promising scaffold for encapsulation of DPSCs and can be considered for cell delivery purposes in tissue engineering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.