ArticleDigestive diseases and sciences2015
Human Immunodeficiency Virus-Associated Diarrhea: Still an Issue in the Era of Antiretroviral Therapy.
Article in Digestive diseases and sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 65 citations in OpenAlex.
- Psychosocial determinants of hand hygiene practices among children and adolescents living with HIV in the Northern city of Malawi.BMC pediatrics · 2026Article
- Multiplex polymerase chain reaction for pathogen identification and antibiotic stewardship in human immunodeficiency virus-associated diarrhea: A retrospective study and systematic review.SAGE open medicine · 2026Review
- Concurrent amebic and cytomegalovirus colitis in immunocompromised patients: two case reports and literature review.Frontiers in medicine · 2026Article
- HIV and Diarrhea: Clinical Characteristics and Etiology at a High-Complexity Center in Southwest Colombia.AIDS research and treatment · 2026Article
- The Gut Microbiome in Enteric Viral Infections: Underlying Mechanisms and Therapeutic Approaches.Microorganisms · 2025Review
- Gastrointestinal cytomegalovirus infection in persons with HIV: a retrospective case series study.BMC infectious diseases · 2025Article
- Nutritional Status of Adult People Living with HIV: A Narrative Review.Diseases (Basel, Switzerland) · 2025Review
- Use of minimally invasive tissue sampling to determine the contribution of diarrheal diseases to under-five mortality and associated co-morbidities and co-infections in children with fatal diarrheal diseases in Africa and Bangladesh.PLOS global public health · 2025Article
- Detection of Enteropathogens in Human Immunodeficiency Virus and Non-Human Immunodeficiency Virus-Infected Children with Acute Diarrhea in an Indonesian Tertiary Hospital Using Multiplex Real-Time Polymerase Chain Reaction.Pediatric gastroenterology, hepatology & nutrition · 2024Article
- Assessment of Gastrointestinal Adverse Effects during the First Six Months of "Biktarvy" Antiretroviral Therapy: Age-Related Patterns and Their Relation with Changes of 5 kg Weight Loss/Gain in the Initial Treatment Period.Diseases (Basel, Switzerland) · 2023Article
- Gastrointestinal tract and viral pathogens.World journal of virology · 2023Review
- Prevalence and Patterns of Adverse Drug Events Among Adult Patients with Human Immune Virus Infection on Dolutegravir-Based Antiretroviral Drug Regimens in Amhara Comprehensive Specialized Hospitals, Northwest Ethiopia: A Multicenter Retrospective Follow-Up Study.HIV/AIDS (Auckland, N.Z.) · 2023Article
- Epidemiology and aetiology of moderate to severe diarrhoea in hospitalised patients ≥5 years old living with HIV in South Africa, 2018-2021: A case-control analysis.PLOS global public health · 2023Article
- Global Burden ofViruses · 2022Review
- The influence of hospitalization and HIV severity on gastrointestinal PCR panel evaluation of HIV-related acute diarrhea in New York City: a retrospective, cross-sectional study.Therapeutic advances in gastroenterology · 2022Article
- Article
- Gastrointestinal Diseases in Children Living with HIV.Microorganisms · 2021Review
- Viral infections in inflammatory bowel disease: Tips and tricks for correct management.World journal of gastroenterology · 2021Review
- Intestinal Microsporidia Infection in Leukemic Children: Microscopic and Molecular Detection.Acta parasitologica · 2021Article
- Utilizing Probiotics for the Prevention and Treatment of Gastrointestinal Diseases.Frontiers in microbiology · 2021Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over half of patients with human immunodeficiency virus (HIV) experience diarrhea that contributes negatively to quality of life and adherence to antiretroviral therapy (ART). Opportunistic infectious agents that cause diarrhea in patients with HIV span the array of protozoa, fungi, viruses, and bacteria. With global use of ART, the incidence of diarrhea because of opportunistic infections has decreased; however, the incidence of noninfectious diarrhea has increased. The etiology of noninfectious diarrhea in patients with HIV is multifactorial and includes ART-associated diarrhea and gastrointestinal damage related to HIV infection (i.e., HIV enteropathy). A basic algorithm for the diagnosis of diarrhea in patients with HIV includes physical examination, a review of medical history, assessment of HIV viral load and CD4+ T cell count, stool microbiologic assessment, and endoscopic evaluation, if needed. For patients with negative diagnostic results, the diagnosis of noninfectious diarrhea may be considered. Pharmacologic options for the treatment of noninfectious diarrhea are primarily supportive; however, the use of many unapproved agents is based on unstudied and anecdotal information. In addition, these agents can be associated with treatment-limiting adverse events (AEs), such as drug-drug interactions with ART regimens, abuse liability, and additional gastrointestinal AEs. Currently, crofelemer, an antisecretory agent, is the only therapy approved in the USA for the symptomatic relief of noninfectious diarrhea in patients with HIV on ART.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.