ArticleScientific reports2015
The significance of serum uric acid level in humans with acute paraquat poisoning.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 16 citations in OpenAlex.
- Kidney and lung injury in rats following acute diquat exposure.Experimental and therapeutic medicine · 2022Article
- A novel simple risk model to predict the prognosis of patients with paraquat poisoning.Scientific reports · 2021Article
- The significance of serum HMGB1 level in humans with acute paraquat poisoning.Scientific reports · 2019Observational
- Point-of-care testing in the early diagnosis of acute pesticide intoxication: The example of paraquat.Biomicrofluidics · 2018Review
- Hypokalemia is a biochemical signal of poor prognosis for acute paraquat poisoning within 4 hours.Internal and emergency medicine · 2017Article
- Prognostic value of hematological parameters in patients with paraquat poisoning.Scientific reports · 2016Article
- Abnormal pancreatic enzymes and their prognostic role after acute paraquat poisoning.Scientific reports · 2015Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyperuricemia is a strong and independent predictor of all-cause mortality in cardiovascular disease and has been found to play a role in diseases exacerbated by oxidative stress and inflammation. This study aimed to evaluate whether serum uric acid (UA) level is an indicator of outcome in patients with acute paraquat poisoning. A total of 205 subjects who had attempted suicide by oral ingestion of paraquat were admitted to the emergency room between January 2009 and June 2014. Initial serum UA level and other laboratory parameters were measured. A total of 66 patients died during the 30 days after admission, corresponding to a 32.2% cumulative incidence of mortality. UA levels were higher in non-survivors than survivors (P < 0.001) and 30-day mortality increased with increasing baseline serum UA level (P < 0.001). In a prediction analysis for 30-day mortality, the serum UA level had a cut-off concentration of 284 µmol/L in female patients and 352 µmol/L in male patients. Multivariate Cox proportional hazards regression analyses showed that white blood cell counts and UA were independent prognostic factors. In conclusion, we showed that serum UA may be an independent predictor of 30-day mortality in patients with paraquat poisoning.
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