ArticleCellular and molecular life sciences : CMLS2015
Experimental verification of a conserved intronic microRNA located in the human TrkC gene with a cell type-dependent apoptotic function.
Article in Cellular and molecular life sciences : CMLS, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Identification of a Novel Small RNA Encoded in the Mouse Urokinase Receptor uPAR Gene (Frontiers in molecular neuroscience · 2022Article
- A Novel miRNA Located in theBioMed research international · 2022Article
- Up-Regulation ofCell journal · 2021Article
- MicroRNA and Hemophilia-A Disease: Bioinformatics Prediction and Experimental Analysis.Cell journal · 2021Article
- Implication of TrkC-miR2 in neurotrophin signalling pathway regulation through NGFR transcript targeting.Journal of cellular and molecular medicine · 2021Article
- Identification of a novel intergenic miRNA located between the human DDC and COBL genes with a potential function in cell cycle arrest.Molecular and cellular biochemistry · 2018Article
- Expression and Function of hsa-miR-6165 in Human Cell Lines and During the NT2 Cell Neural Differentiation Process.Journal of molecular neuroscience : MN · 2017Article
- A novel microRNA located in theThe Journal of biological chemistry · 2017Article
- Alternative splicing of the OCC-1 gene generates three splice variants and a novel exonic microRNA, which regulate the Wnt signaling pathway.RNA (New York, N.Y.) · 2017Article
- Experimental verification of a predicted novel microRNA located in human PIK3CA gene with a potential oncogenic function in colorectal cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Hsa-miR-590-5p Interaction with SMAD3 Transcript Supports Its Regulatory Effect on The TGFβ Signaling Pathway.Cell journal · 2016Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
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Abstract
Tropomyosin receptor kinase C (TrkC) is involved in cell survival, apoptosis induction and tumorigenesis. We hypothesized that, similar to p75(NTR) receptor, some of the diverse functions of TrkC could be mediated by a microRNA (miRNA) embedded within the gene. Here, we experimentally verified the expression and processing of two bioinformatically predicted miRNAs named TrkC-miR1-5p and TrkC-miR1-3p. Transfecting a DNA fragment corresponding to the TrkC-premir1 sequence in HEK293t cells caused ~300-fold elevation in the level of mature TrkC-miR1 and also a significant downregulation of its predicted target genes. Furthermore, endogenous TrkC-miR1 was detected in several cell lines and brain tumors confirming its endogenous generation. Furthermore, its orthologous miRNA was detected in developing rat brain. Accordingly, TrkC-miR1 expression was increased during the course of neural differentiation of NT2 cell, whereas its suppression attenuated NT2 differentiation. Consistent with opposite functions of TrkC, TrkC-miR1 overexpression promoted survival and apoptosis in U87 and HEK293t cell lines, respectively. In conclusion, our data report the discovery of a new miRNA with overlapping function to TrkC.
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