ReviewPhysics of life reviews2015
Mapping complex traits as a dynamic system.
Review in Physics of life reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Getting the most out of intensive longitudinal data: a methodological review of workload-injury studies.BMJ open · 2018Pooled it
- Graph statistics theory of individualized quantitative genetics under haplotype-resolved genome assembly.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- An omnigenic interactome model to chart the genetic architecture of individual plants.Horticulture research · 2026Article
- Network stress: a wiring diagram of whole stress genes.Horticulture research · 2026Article
- Decoding the genetic architecture of seed quality traits in mungbean through quantitative trait loci mapping.Frontiers in plant science · 2026Article
- Parental Phasing Study Identified Lineage-Specific Variants Associated with Gene Expression and Epigenetic Modifications in European-Chinese Hybrid Pigs.Animals : an open access journal from MDPI · 2025Article
- A Critical Perspective on the (Neuro)biological Foundations of Language and Linguistic Cognition.Integrative psychological & behavioral science · 2024Review
- Converging functional phenotyping with systems mapping to illuminate the genotype-phenotype associations.Horticulture research · 2024Article
- Exploiting light energy utilization strategies in Populus simonii through multitrait-GWAS: insights from stochastic differential models.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Genome-Wide Network Analysis of Above- and Below-Ground Co-growth inPlant phenomics (Washington, D.C.) · 2024Article
- Competition-cooperation mechanism betweenFrontiers in microbiology · 2023Article
- The genetic architecture of trait covariation inFrontiers in plant science · 2023Article
- Unoccupied aerial systems discovered overlooked loci capturing the variation of entire growing period in maize.The plant genome · 2021Article
- Genetic Architecture of Multiphasic Growth Covariation as Revealed by a Nonlinear Mixed Mapping Framework.Frontiers in plant science · 2021Article
- A Holling Functional Response Model for Mapping QTLs Governing Interspecific Interactions.Frontiers in genetics · 2021Article
- Heterophylly Quantitative Trait Loci Respond to Salt Stress in the Desert TreeFrontiers in plant science · 2021Article
- A Multilayer Interactome Network Constructed in a Forest Poplar Population Mediates the Pleiotropic Control of Complex Traits.Frontiers in genetics · 2021Article
- Article
- Functional QTL mapping and genomic prediction of canopy height in wheat measured using a robotic field phenotyping platform.Journal of experimental botany · 2020Article
- Predictive ability of genome-assisted statistical models under various forms of gene action.Scientific reports · 2018Article
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Authors and funding
2 authors.
Funding
Abstract
Despite increasing emphasis on the genetic study of quantitative traits, we are still far from being able to chart a clear picture of their genetic architecture, given an inherent complexity involved in trait formation. A competing theory for studying such complex traits has emerged by viewing their phenotypic formation as a "system" in which a high-dimensional group of interconnected components act and interact across different levels of biological organization from molecules through cells to whole organisms. This system is initiated by a machinery of DNA sequences that regulate a cascade of biochemical pathways to synthesize endophenotypes and further assemble these endophenotypes toward the end-point phenotype in virtue of various developmental changes. This review focuses on a conceptual framework for genetic mapping of complex traits by which to delineate the underlying components, interactions and mechanisms that govern the system according to biological principles and understand how these components function synergistically under the control of quantitative trait loci (QTLs) to comprise a unified whole. This framework is built by a system of differential equations that quantifies how alterations of different components lead to the global change of trait development and function, and provides a quantitative and testable platform for assessing the multiscale interplay between QTLs and development. The method will enable geneticists to shed light on the genetic complexity of any biological system and predict, alter or engineer its physiological and pathological states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.