ArticlePsychopharmacology2015
Basolateral amygdala and ventral hippocampus in stress-induced amplification of nicotine self-administration during reacquisition in rat.
Article in Psychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Sex-specific fear acquisition following early life stress is linked to amygdala and hippocampal purine and glutamate metabolism.Communications biology · 2024Article
- Inactivation of phosphodiesterase-4B gene in rat nucleus accumbens shell by CRISPR/Cas9 or positive allosteric modulation of the protein affects the motivation to chronically self-administer nicotine.Scientific reports · 2024Article
- Neurobiology of Stress-Induced Nicotine Relapse.International journal of molecular sciences · 2024Review
- Article
- GABACurrent topics in behavioral neurosciences · 2022Article
- Nerve injury alters restraint-induced activation of the basolateral amygdala in male rats.Brain structure & function · 2021Article
- Disconnecting surgery at alveus and cornu ammonis of hippocampus, amygdala superficialis, and amygdala medial nuclei for epilepsy associated with attention deficit hyperactivity disorder.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- The reinforcement threshold and elasticity of demand for nicotine in an adolescent rat model of depression.Drug and alcohol dependence · 2021Article
- Cocaine and chronic stress exposure produce an additive increase in neuronal activity in the basolateral amygdala.Addiction biology · 2021Article
- Allosteric Modulation of GABAACS pharmacology & translational science · 2020Article
- Dissociable and Paradoxical Roles of Rat Medial and Lateral Orbitofrontal Cortex in Visual Serial Reversal Learning.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Basolateral amygdala and stress-induced hyperexcitability affect motivated behaviors and addiction.Translational psychiatry · 2017Review
- Role of Ventral Subiculum in Context-Induced Relapse to Alcohol Seeking after Punishment-Imposed Abstinence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Commonalities and Distinctions Among Mechanisms of Addiction to Alcohol and Other Drugs.Alcoholism, clinical and experimental research · 2015Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleCigarette smoking remains the leading cause of preventable morbidity and mortality in the USA, although only 3-5 % of quitters are successful for 6-12 months. Stress during abstinence increases the likelihood of relapse to smoking. We recently reported that repeated stress during abstinence from operant nicotine self-administration (SA) amplifies the reacquisition of nicotine SA and affects the diurnal intake of nicotine in rats. Herein, we sought to identify brain regions critical for the expression of stress-enhanced nicotine SA during reacquisition.
methodsRats acquired nicotine SA (FR5) with virtually unlimited drug access (23 h/day). During abstinence (8 day), 30 min of restraint stress was applied on days 1, 3, 5, and 7. Beginning day 8, nicotine SA was reacquired over 5 days, and basolateral amygdala (BLA) was inactivated bilaterally or disconnected from nucleus accumbens core (NAcc). Similarly, ventral hippocampus (vHP) was inactivated or disconnected from BLA.
resultsBilateral inactivation (muscimol + baclofen) of BLA or disconnection from NAcc abolished the stress-enhanced reacquisition of nicotine SA without affecting basal levels of nicotine SA. Similarly, bilateral inactivation of vHP or disconnection of vHP and BLA also abolished stress-enhanced reacquisition of nicotine SA.
conclusionBLA, vHP, and functional interactions between BLA-NAcc and vHP-BLA are required for expression of stress-enhanced nicotine SA during reacquisition. However, without stress, these functional interactions are not necessary for reexpression of nicotine SA during reacquisition. Therefore, BLA, vHP, and these regional interactions specifically mediate the effects of repeated stress on the reacquisition of nicotine SA behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.