ArticleDevelopment genes and evolution2015
Vasa, PL10, and Piwi gene expression during caudal regeneration of the polychaete annelid Alitta virens.
Article in Development genes and evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Transcriptomic analysis of three annelid species: looking for markers of positional information.BMC genomics · 2026Article
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- SoxC and MmpReg promote blastema formation in whole-body regeneration of fragmenting potworms Enchytraeus japonensis.Nature communications · 2024Article
- Annelid adult cell type diversity and their pluripotent cellular origins.Nature communications · 2024Article
- Review
- Germ Line/Multipotency Genes Show Differential Expression during Embryonic Development of the AnnelidBiology · 2023Article
- Article
- Article
- Cell Proliferation Indices in RegeneratingCells · 2023Article
- Transposon control as a checkpoint for tissue regeneration.Development (Cambridge, England) · 2022Article
- A pan-metazoan concept for adult stem cells: the wobbling Penrose landscape.Biological reviews of the Cambridge Philosophical Society · 2022Article
- Article
- Regeneration in the Segmented AnnelidGenes · 2021Review
- Comparative genomic and transcriptomic analyses of transposable elements in polychaetous annelids highlight LTR retrotransposon diversity and evolution.Mobile DNA · 2021Article
- Comparative Aspects of Annelid Regeneration: Towards Understanding the Mechanisms of Regeneration.Genes · 2021Review
- Article
- Injury-Induced Innate Immune Response During Segment Regeneration of the Earthworm,International journal of molecular sciences · 2021Article
- It Cuts Both Ways: An Annelid Model System for the Study of Regeneration in the Laboratory and in the Classroom.Frontiers in cell and developmental biology · 2021Review
- Expression ofGenes · 2020Article
- Article
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Authors and funding
2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Polychaetes are famous for their outstanding ability to regenerate lost body parts. Moreover, these worms possess a number of ancestral features in anatomy, development, and genetics, making them particularly suitable for comparative studies. Thus, fundamental as well as new undisclosed so far features of regenerative processes may be revealed, using polychaetes as a model. In the present work, we aimed to analyze the molecular basis of caudal regeneration in the nereid polychaete Alitta virens (formerly Nereis virens). We focused on homologues genes of RNA helicases Vasa and PL10 and ncRNA-binding proteins Piwi. These markers are suggested to play a significant role in maintenance of undifferentiated state of primordial germ cells and multipotent stem cells across invertebrates. In normal conditions, A. virens homologues of Vasa, PL10, and Piwi were differentially expressed in the subterminal growth zone and germline cells. Caudal amputation induced expression of studied genes de novo, which further accompanies all steps of regeneration. An early appearance of the transcripts in wound epithelium and internal blastemal cells suggests involvement of these genes in the well-known cell dedifferentiation events that assure polychaete regeneration. Provided interpretation of the gene expression dynamics implies the primary restoration of the pygidium and growth zone, which promotes following segment formation. Obtained results are valuable as a molecular fingerprint of the alterations occurring in regulatory state of locally regenerating tissues.
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