ArticleScientific reports2015
Nr0b1 is a negative regulator of Zscan4c in mouse embryonic stem cells.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- The impact of retrotransposons on zygotic genome activation and the chromatin landscape of early embryos.Annals of the New York Academy of Sciences · 2024Review
- Dex-Benchmark: datasets and code to evaluate algorithms for transcriptomics data analysis.PeerJ · 2023Article
- Loss of full-length DNA replication regulator Rif1 in two-cell embryos is associated with zygotic transcriptional activation.The Journal of biological chemistry · 2021Article
- The combined action of Esrrb and Nr5a2 is essential for murine naïve pluripotency.Development (Cambridge, England) · 2021Article
- Cooperation between HDAC3 and DAX1 mediates lineage restriction of embryonic stem cells.The EMBO journal · 2021Article
- Pluripotency-State-Dependent Role of Dax1 in Embryonic Stem Cells Self-Renewal.Stem cells international · 2021Article
- MLL1 Inhibition and Vitamin D Signaling Cooperate to Facilitate the Expanded Pluripotency State.Cell reports · 2019Article
- Toll-like receptor mediated inflammation requires FASN-dependent MYD88 palmitoylation.Nature chemical biology · 2019Article
- Dppa2 and Dppa4 directly regulate the Dux-driven zygotic transcriptional program.Genes & development · 2019Article
- A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs.Nature communications · 2018Article
- TGMI: an efficient algorithm for identifying pathway regulators through evaluation of triple-gene mutual interaction.Nucleic acids research · 2018Article
- Totipotency in the mouse.Journal of molecular medicine (Berlin, Germany) · 2017Review
- Ground rules of the pluripotency gene regulatory network.Nature reviews. Genetics · 2017Review
- Expression analysis of the endogenous Zscan4 locus and its coding proteins in mouse ES cells and preimplantation embryos.In vitro cellular & developmental biology. Animal · 2017Article
- MERVL/Zscan4 Network Activation Results in Transient Genome-wide DNA Demethylation of mESCs.Cell reports · 2016Article
- Epigenetic modifications promote the expression of the orphan nuclear receptor NR0B1 in human lung adenocarcinoma cells.Oncotarget · 2016Article
- Emergence of undifferentiated colonies from mouse embryonic stem cells undergoing differentiation by retinoic acid treatment.In vitro cellular & developmental biology. Animal · 2016Article
- Zscan4 Is Activated after Telomere Shortening in Mouse Embryonic Stem Cells.Stem cell reports · 2016Article
- Tcstv1 and Tcstv3 elongate telomeres of mouse ES cells.Scientific reports · 2016Article
- ETS-related transcription factors ETV4 and ETV5 are involved in proliferation and induction of differentiation-associated genes in embryonic stem (ES) cells.The Journal of biological chemistry · 2015Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nuclear receptor subfamily 0, group B, member 1 (Nr0b1, also known as Dax1) is regarded as an important component of the transcription factor network that governs pluripotency in mouse embryonic stem (ES) cells. Here we generated inducible knockout ES cells for Nr0b1 using the Cre-loxP system and analyzed its precise function. We succeeded in establishing the Nr0b1-null ES cells and confirmed their pluripotency by showing their contribution to chimeric embryos. However, they proliferated slowly with over-expression of 2-cell stage specific transcripts including Zscan4c, which is known to be involved in telomere elongation in ES cells. We revealed that over-expression of Zscan4c prevents normal self-renewal by inducing arrest at G2 phase followed by cell death and that Nr0b1 directly represses the Zscan4c promoter. These data indicated that Nr0b1 is not essential to maintain pluripotency but is involved in the proper activation of 2-cell specific transcripts for self-renewal.
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