ReviewNeurotoxicology and teratology
Carbon monoxide pollution and neurodevelopment: A public health concern.
Review in Neurotoxicology and teratology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 172 citations in OpenAlex.
- Does air pollution exposure affect semen quality? Evidence from a systematic review and meta-analysis of 93,996 Chinese men.Frontiers in public health · 2023Pooled it
- CO and NO Detection by MNJournal of computational chemistry · 2026Article
- Point source capture with storage yields superior aviation health benefits over direct air capture.Eco-Environment & Health · 2026Article
- Effects of climate and air pollution on rates of hospitalization for affective mood disorders in southern Brazil.Scientific reports · 2026Article
- Indoor and outdoor fine particulate matter and carbon monoxide concentrations in homes of infants in Nairobi, Kenya.PLOS global public health · 2026Article
- Sensitive periods for exposure to indoor air pollutants and psychosocial factors in association with symptoms of psychopathology at school-age in a South African birth cohort.Environmental pollution (Barking, Essex : 1987) · 2025Article
- The Effects of Air Pollution on Neurological Diseases: A Narrative Review on Causes and Mechanisms.Toxics · 2025Review
- Harnessing Gasotransmitters to Combat Age-Related Oxidative Stress in Smooth Muscle and Endothelial Cells.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Carbon Monoxide Poisoning: Diagnosis, Prognostic Factors, Treatment Strategies, and Future Perspectives.Diagnostics (Basel, Switzerland) · 2025Review
- Unravelling the Cu and Ce Effects in MnONanomaterials (Basel, Switzerland) · 2025Article
- The role of patient-specific variables in protein corona formation and therapeutic efficacy in nanomedicine.Journal of nanobiotechnology · 2024Review
- Multigenerational association between smoking and autism spectrum disorder: findings from a nationwide prospective cohort study.American journal of epidemiology · 2024Article
- Dataset of air pollutants (PMData in brief · 2024Article
- Impact of air pollution and climate change on mental health outcomes: an umbrella review of global evidence.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2024Article
- Effects of urban-induced mutations on ecology, evolution and health.Nature ecology & evolution · 2024Review
- Unseen crisis: Revealing the hidden health impact of indoor air pollution-A scoping review.Journal of education and health promotion · 2024Article
- Indoor air pollution exposure and early childhood development in the Upstate KIDS Study.Environmental research · 2023Article
- Measuring the Air Quality Using Low-Cost Air Sensors in a Parking Garage at University of Minnesota, USA.International journal of environmental research and public health · 2022Article
- Use of biomass fuels predicts indoor particulate matter and carbon monoxide concentrations; evidence from an informal urban settlement in Fort Portal city, Uganda.BMC public health · 2022Article
- In-utero exposure to indoor air pollution or tobacco smoke and cognitive development in a South African birth cohort study.The Science of the total environment · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Although an association between air pollution and adverse systemic health effects has been known for years, the effect of pollutants on neurodevelopment has been underappreciated. Recent evidence suggests a possible link between air pollution and neurocognitive impairment and behavioral disorders in children, however, the exact nature of this relationship remains poorly understood. Infants and children are uniquely vulnerable due to the potential for exposure in both the fetal and postnatal environments during critical periods in development. Carbon monoxide (CO), a common component of indoor and outdoor air pollution, can cross the placenta to gain access to the fetal circulation and the developing brain. Thus, CO is of particular interest as a known neurotoxin and a potential public health threat. Here we review overt CO toxicity and the policies regulating CO exposure, detail the evidence suggesting a potential link between CO-associated ambient air pollution, tobacco smoke, and learning and behavioral abnormalities in children, describe the effects of subclinical CO exposure on the brain during development, and provide mechanistic insight into a potential connection between CO exposure and neurodevelopmental outcome. CO can disrupt a number of critical processes in the developing brain, providing a better understanding of how this specific neurotoxin may impair neurodevelopment. However, further investigation is needed to better define the effects of perinatal CO exposure on the immature brain. Current policies regarding CO standards were established based on evidence of cardiovascular risk in adults with pre-existing comorbidities. Thus, recent and emerging data highlighted in this review regarding CO exposure in the fetus and developing child may be important to consider when the standards and guidelines are evaluated and revised in the future.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.