Evidence map›Paper›PMID 25771887›Full record

ArticleEndocrine2015

The possible role of CD4⁺CD25(high)Foxp3⁺/CD4⁺IL-17A⁺ cell imbalance in the autoimmunity of patients with Hashimoto thyroiditis.

Haibo Xue, Xiurong Yu, Lei Ma, Shoujun Song, Yuanbin Li, Li Zhang, Tingting Yang, Huan Liu

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Endocrine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06527859 (Correlation Between Different Doses of Levothyroxine Supplementation and Peripheral Blood Th17/Treg Balance in Pregnant Women With Normal-high TSH and Positive TPOAb in the First Half of Pregnancy), which is not on this map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06527859 terminatednot on this mapstarted 2022, after this paper: background citation

Correlation Between Different Doses of Levothyroxine Supplementation and Peripheral Blood Th17/Treg Balance in Pregnant Women With Normal-high TSH and Positive TPOAb in the First Half of Pregnancy

TypeobservationalSponsorThird Affiliated Hospital of Zhengzhou UniversityRan2022 to 2024Enrolled64ConditionsPregnancy Related, Thyroid Stimulating, Hormone, CArmsLevothyroxin
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.

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  8. HuR ablation destabilizesFrontiers in immunology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Haibo XueDepartment of Endocrinology and Metabolism, Binzhou Medical University Hospital, Binzhou, China.
Xiurong YuInternational Office, Binzhou Medical University Hospital, Binzhou, China.
Lei MaDepartment of Dermatology, Binzhou Medical University Hospital, No. 661 Second Huanghe Road, Binzhou, 256603, China. doctor_malei@hotmail.com.
Shoujun SongDepartment of Endocrinology and Metabolism, Binzhou Medical University Hospital, Binzhou, China.
Yuanbin LiDepartment of Endocrinology and Metabolism, Shanxi Dayi Hospital, Taiyuan, China.
Li ZhangDepartment of Endocrinology and Metabolism, Binzhou Medical University Hospital, Binzhou, China.
Tingting YangDepartment of Endocrinology and Metabolism, Binzhou Medical University Hospital, Binzhou, China.
Huan LiuDepartment of Endocrinology and Metabolism, Binzhou Medical University Hospital, Binzhou, China.
Binzhou University · CNBinzhou Medical University · CNShanxi Dayi Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hashimoto thyroiditis (HT) is a prototypic organ-specific autoimmune thyroid disease, for which the exact etiology remains unclear. The aim of this study was to investigate dynamic changes in regulatory T cell (Treg) and T helper 17 cell (Th17) populations in patients with HT at different stages of thyroid dysfunction, as well as to analyze the possible correlation between the Treg/Th17 cell axis and autoimmune status in HT. We assessed thyroid function and autoantibody serology both in HT patients and in healthy controls (HCs) and divided HT patients into three subgroups according to thyroid function. We then determined the percentages of Treg and Th17 cells in peripheral blood mononuclear cells and analyzed mRNA expression of the Treg and Th17 cell-defining transcription factors Foxp3 and RORγt. In addition, serum levels of TGF-β and IL-17A were assessed. We found that the percentage of Treg cells, Foxp3 mRNA levels, and the ratio of Treg/Th17 cells were all significantly lower in HT patients, while Th17 cell percentages and RORγt mRNA levels were significantly higher. Interestingly, we also observed significant differences in these measurements between HT patient subgroups. Serum IL-17A levels were markedly increased in HT patients, while serum concentrations of TGF-β were lower, compared to HCs. The ratio of Treg/Th17 cells was negatively correlated with the levels of serum thyroperoxidase antibody, thyroglobulin antibody, and thyrotropin (TSH) in HT patients. Taken together, our data suggest that the balance between Treg and Th17 cells shifts in favor of Th17 cells during clinical progression of HT, which is negatively correlated with levels of thyroid-specific autoantibodies and TSH, implying that Treg/Th17 cell imbalance may contribute to thyroid damage in HT.

Indexed as

AdultAutoantibodiesCase-Control StudiesFemaleForkhead Transcription FactorsHashimoto DiseaseHumansInterleukin-17Interleukin-2 Receptor alpha SubunitMaleNuclear Receptor Subfamily 1, Group F, Member 3Th17 CellsT-Lymphocytes, RegulatoryTransforming Growth Factor betaYoung AdultAutoantibodiesForkhead Transcription FactorsFOXP3 protein, humanIL17A protein, humanIL2RA protein, humanInterleukin-17Interleukin-2 Receptor alpha SubunitNuclear Receptor Subfamily 1, Group F, Member 3RORC protein, humanTransforming Growth Factor betaAutoimmunityHashimoto thyroiditisRegulatory T cellT helper 17 cellThyroid function

Identifiers

PMID25771887
OpenAlexW1978963663

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.